8OUU

Crystal structure of D1228V c-MET bound by compound 29

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	DIAMOND BEAMLINE I04
Synchrotron site	Diamond
Beamline	I04
Temperature [K]	100
Detector technology	PIXEL
Collection date	2019-09-09
Detector	DECTRIS PILATUS 6M
Wavelength(s)	0.91589
Spacegroup name	P 21 21 21
Unit cell lengths	53.626, 56.738, 214.771
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	54.860 - 1.770
R-factor	0.2033
Rwork	0.202
R-free	0.22510
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.009
RMSD bond angle	0.910
Data reduction software	DIALS
Data scaling software	DIALS
Phasing software	PHASER
Refinement software	BUSTER (2.11.8 (8-JUN-2022))

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	71.590	1.800
High resolution limit [Å]	1.770	1.770
Number of reflections	64902	3094
<I/σ(I)>	9.5
Completeness [%]	99.9
Redundancy	6.1
CC(1/2)	0.998	0.729

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		293	2 M Na formate, 0.1 M Na acetate pH 4.6