8OR0

CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cullin-1	polymer	813	93730.7	1	UniProt (Q13616) Pfam (PF00888) Pfam (PF10557)	Homo sapiens (human)	CUL-1
2	B (B)	E3 ubiquitin-protein ligase RBX1	polymer	108	12290.0	1	UniProt (P62877) Pfam (PF12678)	Homo sapiens (human)	E3 ubiquitin-protein transferase RBX1,Protein ZYP,RING finger protein 75,RING-box protein 1,Rbx1,Regulator of cullins 1,ROC1
3	C (C)	Cullin-associated NEDD8-dissociated protein 1	polymer	1238	137358.2	1	UniProt (Q86VP6) Pfam (PF13513) Pfam (PF08623)	Homo sapiens (human)	Cullin-associated and neddylation-dissociated protein 1,TBP-interacting protein of 120 kDa A,TBP-interacting protein 120A,p120 CAND1
4	D (D)	S-phase kinase-associated protein 1	polymer	163	18680.0	1	UniProt (P63208) Pfam (PF03931) Pfam (PF01466)	Homo sapiens (human)	Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1
5	E (E)	S-phase kinase-associated protein 2	polymer	429	48335.3	1	UniProt (Q13309) Pfam (PF12937)	Homo sapiens (human)	Cyclin-A/CDK2-associated protein p45,F-box protein Skp2,F-box/LRR-repeat protein 1,p45skp2
6	F (G)	Cyclin-dependent kinases regulatory subunit 1	polymer	74	8894.1	1	UniProt (P61024) Pfam (PF01111)	Homo sapiens (human)	CKS-1
7	G (H)	Cyclin-dependent kinase 2	polymer	298	33976.5	1	UniProt (P24941) Pfam (PF00069)	Homo sapiens (human)	Cell division protein kinase 2,p33 protein kinase
8	H, I, J (B)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)

Sequence modifications

A: 1 - 776 (UniProt: Q13616)

PDB	External Database	Details
Met -36	-	initiating methionine
Trp -35	-	expression tag
Ser -34	-	expression tag
His -33	-	expression tag
Pro -32	-	expression tag
Gln -31	-	expression tag
Phe -30	-	expression tag
Glu -29	-	expression tag
Lys -28	-	expression tag
Gly -27	-	expression tag
Ser -26	-	expression tag
Ala -25	-	expression tag
Gly -24	-	expression tag
Ser -23	-	expression tag
Ala -22	-	expression tag
Ala -21	-	expression tag
Gly -20	-	expression tag
Ser -19	-	expression tag
Gly -18	-	expression tag
Ala -17	-	expression tag
Gly -16	-	expression tag
Trp -15	-	expression tag
Ser -14	-	expression tag
His -13	-	expression tag
Pro -12	-	expression tag
Gln -11	-	expression tag
Phe -10	-	expression tag
Glu -9	-	expression tag
Lys -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

C: 1 - 1230 (UniProt: Q86VP6)

PDB	External Database	Details
Gly -7	-	expression tag
Ser -6	-	expression tag
Pro -5	-	expression tag
Glu -4	-	expression tag
Phe -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

E: 1 - 424 (UniProt: Q13309)

PDB	External Database	Details
Gly -4	-	expression tag
Ser -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

G: 1 - 73 (UniProt: P61024)

PDB	External Database	Details
Gly 0	-	expression tag
Pro 1	Met 1	conflict
Leu 2	Ser 2	conflict
Gly 3	His 3	conflict
Ser 4	Lys 4	conflict

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	353264.7
Non-Polymers*	Number of molecules	3
	Total formula weight	196.2
All*	Total formula weight	353461.0

*Water molecules are not included.