Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8OR0

CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006915	biological_process	apoptotic process
A	0007040	biological_process	lysosome organization
A	0008283	biological_process	cell population proliferation
A	0009887	biological_process	animal organ morphogenesis
A	0010507	biological_process	negative regulation of autophagy
A	0010508	biological_process	positive regulation of autophagy
A	0016567	biological_process	protein ubiquitination
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031461	cellular_component	cullin-RING ubiquitin ligase complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031669	biological_process	cellular response to nutrient levels
A	0034599	biological_process	cellular response to oxidative stress
A	0038202	biological_process	TORC1 signaling
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0070936	biological_process	protein K48-linked ubiquitination
A	0097193	biological_process	intrinsic apoptotic signaling pathway
A	0140374	biological_process	antiviral innate immune response
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1904037	biological_process	positive regulation of epithelial cell apoptotic process
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
B	0000045	biological_process	autophagosome assembly
B	0000082	biological_process	G1/S transition of mitotic cell cycle
B	0000165	biological_process	MAPK cascade
B	0000209	biological_process	protein polyubiquitination
B	0000423	biological_process	mitophagy
B	0001837	biological_process	epithelial to mesenchymal transition
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006283	biological_process	transcription-coupled nucleotide-excision repair
B	0006366	biological_process	transcription by RNA polymerase II
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006513	biological_process	protein monoubiquitination
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007040	biological_process	lysosome organization
B	0007283	biological_process	spermatogenesis
B	0007346	biological_process	regulation of mitotic cell cycle
B	0008270	molecular_function	zinc ion binding
B	0008286	biological_process	insulin receptor signaling pathway
B	0010507	biological_process	negative regulation of autophagy
B	0010508	biological_process	positive regulation of autophagy
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0019005	cellular_component	SCF ubiquitin ligase complex
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0019788	molecular_function	NEDD8 transferase activity
B	0030163	biological_process	protein catabolic process
B	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
B	0030891	cellular_component	VCB complex
B	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B	0031461	cellular_component	cullin-RING ubiquitin ligase complex
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
B	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
B	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031669	biological_process	cellular response to nutrient levels
B	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0032480	biological_process	negative regulation of type I interferon production
B	0032481	biological_process	positive regulation of type I interferon production
B	0032869	biological_process	cellular response to insulin stimulus
B	0034198	biological_process	cellular response to amino acid starvation
B	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
B	0034599	biological_process	cellular response to oxidative stress
B	0034644	biological_process	cellular response to UV
B	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
B	0038066	biological_process	p38MAPK cascade
B	0038202	biological_process	TORC1 signaling
B	0042110	biological_process	T cell activation
B	0042770	biological_process	signal transduction in response to DNA damage
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043687	biological_process	post-translational protein modification
B	0044877	molecular_function	protein-containing complex binding
B	0045116	biological_process	protein neddylation
B	0045727	biological_process	positive regulation of translation
B	0045732	biological_process	positive regulation of protein catabolic process
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046627	biological_process	negative regulation of insulin receptor signaling pathway
B	0046872	molecular_function	metal ion binding
B	0060090	molecular_function	molecular adaptor activity
B	0060337	biological_process	type I interferon-mediated signaling pathway
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0061663	molecular_function	NEDD8 ligase activity
B	0062197	biological_process	cellular response to chemical stress
B	0070294	biological_process	renal sodium ion absorption
B	0070936	biological_process	protein K48-linked ubiquitination
B	0071230	biological_process	cellular response to amino acid stimulus
B	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
B	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
B	0090734	cellular_component	site of DNA damage
B	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
B	0097602	molecular_function	cullin family protein binding
B	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B	0160240	biological_process	RNA polymerase II transcription initiation surveillance
B	1900076	biological_process	regulation of cellular response to insulin stimulus
B	1901525	biological_process	negative regulation of mitophagy
B	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
B	1902499	biological_process	positive regulation of protein autoubiquitination
B	1902883	biological_process	negative regulation of response to oxidative stress
B	1904037	biological_process	positive regulation of epithelial cell apoptotic process
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1904263	biological_process	positive regulation of TORC1 signaling
B	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
C	0000151	cellular_component	ubiquitin ligase complex
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0010265	biological_process	SCF complex assembly
C	0016020	cellular_component	membrane
C	0016567	biological_process	protein ubiquitination
C	0017025	molecular_function	TBP-class protein binding
C	0030154	biological_process	cell differentiation
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0034774	cellular_component	secretory granule lumen
C	0043086	biological_process	negative regulation of catalytic activity
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
C	0070062	cellular_component	extracellular exosome
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000209	biological_process	protein polyubiquitination
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006338	biological_process	chromatin remodeling
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006915	biological_process	apoptotic process
D	0008013	molecular_function	beta-catenin binding
D	0016567	biological_process	protein ubiquitination
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019904	molecular_function	protein domain specific binding
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031519	cellular_component	PcG protein complex
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051457	biological_process	maintenance of protein location in nucleus
D	0061564	biological_process	axon development
D	0070936	biological_process	protein K48-linked ubiquitination
D	0097602	molecular_function	cullin family protein binding
D	0140677	molecular_function	molecular function activator activity
D	0160072	molecular_function	ubiquitin ligase complex scaffold activity
D	1904037	biological_process	positive regulation of epithelial cell apoptotic process
D	1990444	molecular_function	F-box domain binding
D	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
D	1990757	molecular_function	ubiquitin ligase activator activity
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000209	biological_process	protein polyubiquitination
E	0000729	biological_process	DNA double-strand break processing
E	0002376	biological_process	immune system process
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0016567	biological_process	protein ubiquitination
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0033148	biological_process	positive regulation of intracellular estrogen receptor signaling pathway
E	0042802	molecular_function	identical protein binding
E	0042981	biological_process	regulation of apoptotic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0045087	biological_process	innate immune response
E	0048661	biological_process	positive regulation of smooth muscle cell proliferation
E	0051607	biological_process	defense response to virus
E	0051726	biological_process	regulation of cell cycle
E	0070534	biological_process	protein K63-linked ubiquitination
E	0070936	biological_process	protein K48-linked ubiquitination
E	0071460	biological_process	cellular response to cell-matrix adhesion
E	1902916	biological_process	positive regulation of protein polyubiquitination
E	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
E	1990166	biological_process	protein localization to site of double-strand break
E	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
G	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0007346	biological_process	regulation of mitotic cell cycle
G	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
G	0019005	cellular_component	SCF ubiquitin ligase complex
G	0019901	molecular_function	protein kinase binding
G	0042393	molecular_function	histone binding
G	0043130	molecular_function	ubiquitin binding
G	0051301	biological_process	cell division
G	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
H	0000082	biological_process	G1/S transition of mitotic cell cycle
H	0000086	biological_process	G2/M transition of mitotic cell cycle
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
H	0000723	biological_process	telomere maintenance
H	0000781	cellular_component	chromosome, telomeric region
H	0000793	cellular_component	condensed chromosome
H	0000805	cellular_component	X chromosome
H	0000806	cellular_component	Y chromosome
H	0001673	cellular_component	male germ cell nucleus
H	0004672	molecular_function	protein kinase activity
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005635	cellular_component	nuclear envelope
H	0005654	cellular_component	nucleoplasm
H	0005667	cellular_component	transcription regulator complex
H	0005737	cellular_component	cytoplasm
H	0005768	cellular_component	endosome
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0006260	biological_process	DNA replication
H	0006281	biological_process	DNA repair
H	0006338	biological_process	chromatin remodeling
H	0006351	biological_process	DNA-templated transcription
H	0006468	biological_process	protein phosphorylation
H	0006813	biological_process	potassium ion transport
H	0006974	biological_process	DNA damage response
H	0007099	biological_process	centriole replication
H	0007165	biological_process	signal transduction
H	0007265	biological_process	Ras protein signal transduction
H	0007346	biological_process	regulation of mitotic cell cycle
H	0008284	biological_process	positive regulation of cell population proliferation
H	0010389	biological_process	regulation of G2/M transition of mitotic cell cycle
H	0010468	biological_process	regulation of gene expression
H	0015030	cellular_component	Cajal body
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0018105	biological_process	peptidyl-serine phosphorylation
H	0019904	molecular_function	protein domain specific binding
H	0030332	molecular_function	cyclin binding
H	0031453	biological_process	positive regulation of heterochromatin formation
H	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
H	0031848	biological_process	protection from non-homologous end joining at telomere
H	0032298	biological_process	positive regulation of DNA-templated DNA replication initiation
H	0035173	molecular_function	histone kinase activity
H	0043247	biological_process	telomere maintenance in response to DNA damage
H	0043687	biological_process	post-translational protein modification
H	0045740	biological_process	positive regulation of DNA replication
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0046872	molecular_function	metal ion binding
H	0051298	biological_process	centrosome duplication
H	0051301	biological_process	cell division
H	0051321	biological_process	meiotic cell cycle
H	0071732	biological_process	cellular response to nitric oxide
H	0090398	biological_process	cellular senescence
H	0097123	cellular_component	cyclin A1-CDK2 complex
H	0097124	cellular_component	cyclin A2-CDK2 complex
H	0097134	cellular_component	cyclin E1-CDK2 complex
H	0097135	cellular_component	cyclin E2-CDK2 complex
H	0097472	molecular_function	cyclin-dependent protein kinase activity
H	0106310	molecular_function	protein serine kinase activity
H	1905784	biological_process	regulation of anaphase-promoting complex-dependent catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK

Chain	Residue	Details
H	ILE10-LYS33

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI

Chain	Residue	Details
H	VAL123-ILE135

site_id	PS00944
Number of Residues	19
Details	CKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK

Chain	Residue	Details
G	TYR8-LYS26

site_id	PS00945
Number of Residues	11
Details	CKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR

Chain	Residue	Details
G	HIS60-ARG70

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA

Chain	Residue	Details
A	ILE749-ALA776

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
H	ASP127

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000269\|PubMed:17095507, ECO:0000269\|PubMed:21565702

Chain	Residue	Details
H	ILE10
H	LYS33
H	GLU81
H	ASP86
H	LYS129
B	CYS94
B	ASP97

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:21565702

Chain	Residue	Details
H	ASN132
H	ASP145
B	CYS68
B	HIS82

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: CDK7 binding => ECO:0000269\|PubMed:17373709

Chain	Residue	Details
H	LYS9
H	LYS88
H	LEU166

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
H	MET1

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
H	LYS6

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:1396589, ECO:0000269\|PubMed:17095507

Chain	Residue	Details
H	THR14

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by WEE1 => ECO:0000269\|PubMed:1396589, ECO:0000269\|PubMed:17095507, ECO:0007744\|PubMed:19690332

Chain	Residue	Details
H	TYR15

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:19369195

Chain	Residue	Details
H	TYR19

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CAK and CCRK => ECO:0000269\|PubMed:1396589, ECO:0000269\|PubMed:14597612, ECO:0000269\|PubMed:16325401, ECO:0000269\|PubMed:17095507, ECO:0000269\|PubMed:17570665, ECO:0000269\|PubMed:20147522, ECO:0000269\|PubMed:20360007, ECO:0000269\|PubMed:21565702, ECO:0000305\|PubMed:28666995

Chain	Residue	Details
H	THR160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)