8OOD
Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DDB1- and CUL4-associated factor 1 | polymer | 367 | 41764.8 | 1 | UniProt (Q9Y4B6) In PDB | Homo sapiens (human) | HIV-1 Vpr-binding protein,VprBP,Serine/threonine-protein kinase VPRBP,Vpr-interacting protein |
| 2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | A | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | A | ~{N}-[2-[2-[2-[2-[2-[2-[3-[4-[4-(2-azanylethylamino)-2-[1-(4-chlorophenyl)cyclopentyl]quinazolin-7-yl]piperazin-1-yl]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide | non-polymer | 828.4 | 2 | Chemie (VY3) | |||
| 6 | water | water | 18.0 | 316 | Chemie (HOH) |
Sequence modifications
A: 1039 - 1401 (UniProt: Q9Y4B6)
| PDB | External Database | Details |
|---|---|---|
| Gly 1035 | - | expression tag |
| Gly 1036 | - | expression tag |
| Gly 1037 | - | expression tag |
| Arg 1038 | - | expression tag |
| Leu 1250 | Gln 1250 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41764.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2109.6 | |
| All* | Total formula weight | 43874.4 |
