8ONE
Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Asp190Ser mutant - Cocrystal with Fe2+, Mn2+, UDP-Glucose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 | polymer | 719 | 82813.5 | 1 | UniProt (O60568) Pfam (PF25342) Pfam (PF25238) Pfam (PF03171) | Homo sapiens (human) | |
| 2 | B (L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | C (A) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 1 | Chemie (AKG) PubChem (51) | |||
| 4 | D, E (A) | FE (II) ION | non-polymer | 55.8 | 2 | Chemie (FE2) PubChem (27284) | |||
| 5 | F (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) PubChem (27854) | |||
| 6 | G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | H, I, J (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) PubChem (753) | |||
| 8 | K (A) | URIDINE-5'-DIPHOSPHATE-GLUCOSE | non-polymer | 566.3 | 1 | Chemie (UPG) PubChem (16667381) PubChem (20776702) PubChem (20776703) PubChem (1166) PubChem (25011746) PubChem (16760700) PubChem (20776705) PubChem (20776706) PubChem (45109771) PubChem (23724458) PubChem (46226441) PubChem (46936243) PubChem (53477679) PubChem (56845790) PubChem (58538034) PubChem (439156) PubChem (59720988) PubChem (448801) PubChem (56650783) PubChem (56846106) PubChem (88869506) PubChem (88869507) PubChem (88869743) PubChem (88870643) PubChem (88883029) PubChem (88910951) PubChem (88941526) PubChem (89321600) PubChem (89360378) PubChem (89847362) PubChem (90056247) PubChem (8629) PubChem (18068) PubChem (439158) PubChem (448873) PubChem (640055) PubChem (90950359) PubChem (92328335) PubChem (92974127) PubChem (91746280) PubChem (6857410) PubChem (124933210) PubChem (92974126) PubChem (92974128) PubChem (92974129) PubChem (93535589) PubChem (129850353) PubChem (6857540) PubChem (102429624) PubChem (11734460) PubChem (12133414) PubChem (13008857) PubChem (13987142) PubChem (124933209) PubChem (155893098) PubChem (158571248) PubChem (162920685) PubChem (168265389) PubChem (134736387) PubChem (134736388) PubChem (138911444) PubChem (162920683) PubChem (162920684) PubChem (163626061) PubChem (166642644) PubChem (168720052) PubChem (174027848) | |||
| 9 | L (A) | water | water | 18.0 | 323 | Chemie (HOH) |
Sequence modifications
A: 25 - 738 (UniProt: O60568)
A: 739 - 741 (PDB: 8ONE)
| PDB | External Database | Details |
|---|---|---|
| Gly 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Ser 190 | Asp 190 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 82813.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1376.5 | |
| All* | Total formula weight | 84614.4 |
