8KH7
Crystal structure of FGFR4 kinase domain with 8zc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Fibroblast growth factor receptor 4 | polymer | 311 | 34695.1 | 1 | UniProt (P22455) In PDB | Homo sapiens (human) | FGFR-4 |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A | 1-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[6-methanoyl-5-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3-(2-morpholin-4-ylethoxy)pyridin-2-yl]urea | non-polymer | 712.6 | 1 | Chemie (VVW) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | water | water | 18.0 | 336 | Chemie (HOH) |
Sequence modifications
A: 445 - 753 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Gly 443 | - | expression tag |
| Pro 444 | - | expression tag |
| Glu 664 | Arg 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34695.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 870.7 | |
| All* | Total formula weight | 35565.8 |
