8KEI
Cryo-EM structure of NADPH oxidase 2 in complex with p22phox and EROS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome b-245 light chain | polymer | 133 | 14663.2 | 1 | UniProt (P13498) Pfam (PF05038) | Homo sapiens (human) | Cytochrome b(558) alpha chain,Cytochrome b558 subunit alpha,Neutrophil cytochrome b 22 kDa polypeptide,Superoxide-generating NADPH oxidase light chain subunit,p22 phagocyte B-cytochrome,p22-phox,p22phox |
| 2 | B (B) | Cytochrome b-245 heavy chain | polymer | 565 | 64853.1 | 1 | UniProt (P04839) Pfam (PF01794) Pfam (PF08022) Pfam (PF08030) | Homo sapiens (human) | CGD91-phox,Cytochrome b(558) subunit beta,Cytochrome b558 subunit beta,Heme-binding membrane glycoprotein gp91phox,NADPH oxidase 2,Neutrophil cytochrome b 91 kDa polypeptide,Superoxide-generating NADPH oxidase heavy chain subunit,gp91-1,gp91-phox,p22 phagocyte B-cytochrome |
| 3 | C (C) | monoclonal antibody 7G5 heavy chain | polymer | 224 | 23484.3 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 4 | D (D) | Cytochrome b-245 chaperone 1 | polymer | 164 | 18491.5 | 1 | UniProt (Q9BQA9) Pfam (PF15169) | Homo sapiens (human) | Essential for reactive oxygen species protein,Eros |
| 5 | E (E) | monoclonal antibody 7G5 light chain | polymer | 217 | 23521.2 | 1 | Oryctolagus cuniculus (Rabbit) | ||
| 6 | F, G (F, G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 7 | H (A) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 1 | Chemie (POV) | |||
| 8 | I, J (B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 9 | K (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 10 | L (B) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 1 | Chemie (LBN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 145013.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1173.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2974.3 | |
| All* | Total formula weight | 149160.7 |
