8KEI
Cryo-EM structure of NADPH oxidase 2 in complex with p22phox and EROS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0020037 | molecular_function | heme binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006801 | biological_process | superoxide metabolic process |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006952 | biological_process | defense response |
| B | 0006954 | biological_process | inflammatory response |
| B | 0007584 | biological_process | response to nutrient |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0016020 | cellular_component | membrane |
| B | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
| B | 0016175 | molecular_function | superoxide-generating NAD(P)H oxidase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0030171 | molecular_function | voltage-gated proton channel activity |
| B | 0030425 | cellular_component | dendrite |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0032760 | biological_process | positive regulation of tumor necrosis factor production |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0035579 | cellular_component | specific granule membrane |
| B | 0042554 | biological_process | superoxide anion generation |
| B | 0043020 | cellular_component | NADPH oxidase complex |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0045087 | biological_process | innate immune response |
| B | 0045335 | cellular_component | phagocytic vesicle |
| B | 0045471 | biological_process | response to ethanol |
| B | 0045730 | biological_process | respiratory burst |
| B | 0045766 | biological_process | positive regulation of angiogenesis |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050664 | molecular_function | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor |
| B | 0070402 | molecular_function | NADPH binding |
| B | 0070821 | cellular_component | tertiary granule membrane |
| B | 0071276 | biological_process | cellular response to cadmium ion |
| B | 0071361 | biological_process | cellular response to ethanol |
| B | 0071456 | biological_process | cellular response to hypoxia |
| B | 0071949 | molecular_function | FAD binding |
| B | 0097038 | cellular_component | perinuclear endoplasmic reticulum |
| B | 0097411 | biological_process | hypoxia-inducible factor-1alpha signaling pathway |
| B | 0106292 | molecular_function | superoxide-generating NADPH oxidase activity |
| B | 1904044 | biological_process | response to aldosterone |
| B | 1904845 | biological_process | cellular response to L-glutamine |
| B | 1990776 | biological_process | response to angiotensin |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| E | TYR196-HIS202 | |
| C | TYR203-HIS209 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 226 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"36241643","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36413210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7U8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GZ3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36241643","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36413210","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36241643","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36413210","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Intramembrane: {"evidences":[{"source":"PubMed","id":"36241643","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 85 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36413210","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 30 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36413210","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 232 |
| Details | Domain: {"description":"Ferric oxidoreductase"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"36413210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GZ3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36413210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GZ3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36413210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GZ3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36413210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GZ3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 10 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q61093","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
