8KCT
Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nicastrin | polymer | 701 | 77622.6 | 1 | UniProt (Q92542) Pfam (PF18266) Pfam (PF05450) | Homo sapiens (human) | |
| 2 | B (C) | Gamma-secretase subunit APH-1A | polymer | 265 | 29017.9 | 1 | UniProt (Q96BI3) Pfam (PF06105) | Homo sapiens (human) | APH-1a,Aph-1alpha,Presenilin-stabilization factor |
| 3 | C (D) | Gamma-secretase subunit PEN-2 | polymer | 101 | 12038.0 | 1 | UniProt (Q9NZ42) Pfam (PF10251) | Homo sapiens (human) | Presenilin enhancer protein 2 |
| 4 | D (B) | Presenilin-1 | polymer | 467 | 52713.5 | 1 | UniProt (P49768) Pfam (PF01080) | Homo sapiens (human) | PS-1,Protein S182 |
| 5 | E, G, H, I, J (E, G, H, I, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F (F) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G89225LT) | |||
| 7 | K, L, M, N, O... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) PubChem (24139) | |||
| 8 | Q, R, S (C) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) PubChem (5997) | |||
| 9 | T, U (C, B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) | |||
| 10 | V (B) | Nirogacestat | non-polymer | 489.6 | 1 | Chemie (O6U) PubChem (46224413) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 171392.1 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 3032.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4557.1 | |
| All* | Total formula weight | 178982.1 |
