8KCT
Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. VAATrlDsRSFFWNV |
| Chain | Residue | Details |
| A | VAL277-VAL291 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 206 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| B | MET1-VAL82 | |
| B | TYR154-LEU166 | |
| B | GLY217-ARG220 | |
| B | GLU273-LYS380 | |
| B | LYS429-LEU432 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 186 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| B | ILE83-VAL103 | |
| B | ILE133-LEU153 | |
| B | ILE167-TYR189 | |
| B | TYR195-LYS216 | |
| B | LEU221-LEU241 | |
| B | ILE249-VAL272 | |
| B | LEU381-SER401 | |
| B | ILE408-PHE428 | |
| B | PRO433-VAL453 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 56 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:26280335 |
| Chain | Residue | Details |
| B | SER104-SER132 | |
| B | ASN190-ASP194 | |
| B | PRO242-LEU248 | |
| B | GLY402-THR407 | |
| B | GLN454-ILE467 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:10206644, ECO:0000305|PubMed:10899933, ECO:0000305|PubMed:15341515 |
| Chain | Residue | Details |
| B | ASP257 | |
| A | ASN264 | |
| A | ASN435 | |
| A | ASN464 | |
| A | ASN506 | |
| A | ASN530 | |
| A | ASN562 | |
| A | ASN573 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:10206644, ECO:0000305|PubMed:10899933, ECO:0000305|PubMed:15341515, ECO:0000305|PubMed:30598546, ECO:0000305|PubMed:30630874 |
| Chain | Residue | Details |
| B | ASP385 | |
| A | ASN204 | |
| A | ASN417 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; alternate => ECO:0000269|PubMed:9173929 |
| Chain | Residue | Details |
| B | THR291 | |
| B | MET292 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Cleavage => ECO:0000269|PubMed:9173929 |
| Chain | Residue | Details |
| B | MET298 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by caspase => ECO:0000269|PubMed:9485372 |
| Chain | Residue | Details |
| B | ASP345 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER43 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97887 |
| Chain | Residue | Details |
| B | SER51 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:14576165 |
| Chain | Residue | Details |
| B | SER310 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:14576165 |
| Chain | Residue | Details |
| B | SER346 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER367 |
