8KB8

Structure of the WDR91 WD40 domain complexed with Rab7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	WD repeat-containing protein 91	polymer	363	39824.2	2	UniProt (A4D1P6) Pfam (PF00400)	Homo sapiens (human)
2	C, D (C, D)	Ras-related protein Rab-7a	polymer	181	20410.4	2	UniProt (P51149) Pfam (PF00071)	Homo sapiens (human)
3	E, G (C, D)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	F, H (C, D)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
5	I, J, K, L (A, B, C, D)	water	water		18.0	27	Chemie (HOH)

Sequence modifications

A, B: 392 - 747 (UniProt: A4D1P6)

PDB	External Database	Details
Met 391	-	initiating methionine
His 748	-	expression tag
His 749	-	expression tag
His 750	-	expression tag
His 751	-	expression tag
His 752	-	expression tag
His 753	-	expression tag

C, D: 1 - 176 (UniProt: P51149)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Leu 67	Gln 67	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	120469.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1095.0
All*	Total formula weight	121564.0

*Water molecules are not included.