8K8T

Structure of CUL3-RBX1-KLHL22 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	Cullin-3	polymer	776	90134.6	2	UniProt (Q13618) Pfam (PF00888) Pfam (PF10557)	Homo sapiens (human)
2	C, D (K, L)	Kelch-like protein 22	polymer	660	74978.1	2	UniProt (Q53GT1) Pfam (PF00651) Pfam (PF07707) Pfam (PF13964) Pfam (PF01344) Pfam (PF13415)	Homo sapiens (human)

Sequence modifications

C, D: 1 - 768 (UniProt: Q13618)

PDB	External Database	Details
Lys 769	-	expression tag
Leu 770	-	expression tag
His 771	-	expression tag
His 772	-	expression tag
His 773	-	expression tag
His 774	-	expression tag
His 775	-	expression tag
His 776	-	expression tag

K, L: 1 - 634 (UniProt: Q53GT1)

PDB	External Database	Details
Met -25	-	initiating methionine
Ser -24	-	expression tag
Tyr -23	-	expression tag
Tyr -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
Asp -15	-	expression tag
Tyr -14	-	expression tag
Asp -13	-	expression tag
Ile -12	-	expression tag
Pro -11	-	expression tag
Thr -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	330225.3
All*	Total formula weight	330225.3

*Water molecules are not included.