8K8T

Structure of CUL3-RBX1-KLHL22 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0000209	biological_process	protein polyubiquitination
C	0000278	biological_process	mitotic cell cycle
C	0000922	cellular_component	spindle pole
C	0001822	biological_process	kidney development
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005112	molecular_function	Notch binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005827	cellular_component	polar microtubule
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006915	biological_process	apoptotic process
C	0006950	biological_process	response to stress
C	0006954	biological_process	inflammatory response
C	0007080	biological_process	mitotic metaphase chromosome alignment
C	0007165	biological_process	signal transduction
C	0007229	biological_process	integrin-mediated signaling pathway
C	0008284	biological_process	positive regulation of cell population proliferation
C	0010467	biological_process	gene expression
C	0010468	biological_process	regulation of gene expression
C	0015630	cellular_component	microtubule cytoskeleton
C	0016020	cellular_component	membrane
C	0016192	biological_process	vesicle-mediated transport
C	0016477	biological_process	cell migration
C	0016567	biological_process	protein ubiquitination
C	0017145	biological_process	stem cell division
C	0030030	biological_process	cell projection organization
C	0030163	biological_process	protein catabolic process
C	0030332	molecular_function	cyclin binding
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0031208	molecular_function	POZ domain binding
C	0031398	biological_process	positive regulation of protein ubiquitination
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0031514	cellular_component	motile cilium
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031648	biological_process	protein destabilization
C	0032467	biological_process	positive regulation of cytokinesis
C	0032480	biological_process	negative regulation of type I interferon production
C	0034599	biological_process	cellular response to oxidative stress
C	0035024	biological_process	negative regulation of Rho protein signal transduction
C	0036126	cellular_component	sperm flagellum
C	0040016	biological_process	embryonic cleavage
C	0042802	molecular_function	identical protein binding
C	0043149	biological_process	stress fiber assembly
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
C	0048208	biological_process	COPII vesicle coating
C	0051301	biological_process	cell division
C	0051865	biological_process	protein autoubiquitination
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070062	cellular_component	extracellular exosome
C	0070936	biological_process	protein K48-linked ubiquitination
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
C	0072686	cellular_component	mitotic spindle
C	0080090	biological_process	regulation of primary metabolic process
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0140252	biological_process	regulation protein catabolic process at postsynapse
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1900076	biological_process	regulation of cellular response to insulin stimulus
C	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000209	biological_process	protein polyubiquitination
D	0000278	biological_process	mitotic cell cycle
D	0000922	cellular_component	spindle pole
D	0001822	biological_process	kidney development
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005112	molecular_function	Notch binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005827	cellular_component	polar microtubule
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
D	0006915	biological_process	apoptotic process
D	0006950	biological_process	response to stress
D	0006954	biological_process	inflammatory response
D	0007080	biological_process	mitotic metaphase chromosome alignment
D	0007165	biological_process	signal transduction
D	0007229	biological_process	integrin-mediated signaling pathway
D	0008284	biological_process	positive regulation of cell population proliferation
D	0010467	biological_process	gene expression
D	0010468	biological_process	regulation of gene expression
D	0015630	cellular_component	microtubule cytoskeleton
D	0016020	cellular_component	membrane
D	0016192	biological_process	vesicle-mediated transport
D	0016477	biological_process	cell migration
D	0016567	biological_process	protein ubiquitination
D	0017145	biological_process	stem cell division
D	0030030	biological_process	cell projection organization
D	0030163	biological_process	protein catabolic process
D	0030332	molecular_function	cyclin binding
D	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
D	0031208	molecular_function	POZ domain binding
D	0031398	biological_process	positive regulation of protein ubiquitination
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031514	cellular_component	motile cilium
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031648	biological_process	protein destabilization
D	0032467	biological_process	positive regulation of cytokinesis
D	0032480	biological_process	negative regulation of type I interferon production
D	0034599	biological_process	cellular response to oxidative stress
D	0035024	biological_process	negative regulation of Rho protein signal transduction
D	0036126	cellular_component	sperm flagellum
D	0040016	biological_process	embryonic cleavage
D	0042802	molecular_function	identical protein binding
D	0043149	biological_process	stress fiber assembly
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
D	0048208	biological_process	COPII vesicle coating
D	0051301	biological_process	cell division
D	0051865	biological_process	protein autoubiquitination
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0070062	cellular_component	extracellular exosome
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
D	0072686	cellular_component	mitotic spindle
D	0080090	biological_process	regulation of primary metabolic process
D	0097193	biological_process	intrinsic apoptotic signaling pathway
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0140252	biological_process	regulation protein catabolic process at postsynapse
D	0160072	molecular_function	ubiquitin ligase complex scaffold activity
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1901992	biological_process	positive regulation of mitotic cell cycle phase transition
D	1904263	biological_process	positive regulation of TORC1 signaling
K	0000070	biological_process	mitotic sister chromatid segregation
K	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005827	cellular_component	polar microtubule
K	0005829	cellular_component	cytosol
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006513	biological_process	protein monoubiquitination
K	0007094	biological_process	mitotic spindle assembly checkpoint signaling
K	0010507	biological_process	negative regulation of autophagy
K	0016567	biological_process	protein ubiquitination
K	0030307	biological_process	positive regulation of cell growth
K	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K	0032480	biological_process	negative regulation of type I interferon production
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045171	cellular_component	intercellular bridge
K	0050870	biological_process	positive regulation of T cell activation
K	0051301	biological_process	cell division
K	0071230	biological_process	cellular response to amino acid stimulus
K	0071233	biological_process	cellular response to L-leucine
K	0071889	molecular_function	14-3-3 protein binding
K	0072686	cellular_component	mitotic spindle
K	1904263	biological_process	positive regulation of TORC1 signaling
K	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
L	0000070	biological_process	mitotic sister chromatid segregation
L	0002842	biological_process	positive regulation of T cell mediated immune response to tumor cell
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005813	cellular_component	centrosome
L	0005819	cellular_component	spindle
L	0005827	cellular_component	polar microtubule
L	0005829	cellular_component	cytosol
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006513	biological_process	protein monoubiquitination
L	0007094	biological_process	mitotic spindle assembly checkpoint signaling
L	0010507	biological_process	negative regulation of autophagy
L	0016567	biological_process	protein ubiquitination
L	0030307	biological_process	positive regulation of cell growth
L	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
L	0032480	biological_process	negative regulation of type I interferon production
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0045171	cellular_component	intercellular bridge
L	0050870	biological_process	positive regulation of T cell activation
L	0051301	biological_process	cell division
L	0071230	biological_process	cellular response to amino acid stimulus
L	0071233	biological_process	cellular response to L-leucine
L	0071889	molecular_function	14-3-3 protein binding
L	0072686	cellular_component	mitotic spindle
L	1904263	biological_process	positive regulation of TORC1 signaling
L	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkrIegLIEReYLaRtpedrkvYtYvA

Chain	Residue	Details
C	ILE741-ALA768

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	134
Details	Domain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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