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8K8T

Structure of CUL3-RBX1-KLHL22 complex

Functional Information from GO Data
ChainGOidnamespacecontents
C0000082biological_processG1/S transition of mitotic cell cycle
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000209biological_processprotein polyubiquitination
C0000278biological_processmitotic cell cycle
C0000902biological_processcell morphogenesis
C0000922cellular_componentspindle pole
C0001701biological_processin utero embryonic development
C0001822biological_processkidney development
C0001831biological_processtrophectodermal cellular morphogenesis
C0004842molecular_functionubiquitin-protein transferase activity
C0005112molecular_functionNotch binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005827cellular_componentpolar microtubule
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006357biological_processregulation of transcription by RNA polymerase II
C0006366biological_processtranscription by RNA polymerase II
C0006368biological_processtranscription elongation by RNA polymerase II
C0006511biological_processubiquitin-dependent protein catabolic process
C0006513biological_processprotein monoubiquitination
C0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
C0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
C0006915biological_processapoptotic process
C0006950biological_processresponse to stress
C0006954biological_processinflammatory response
C0006979biological_processresponse to oxidative stress
C0007080biological_processmitotic metaphase chromosome alignment
C0007165biological_processsignal transduction
C0007229biological_processintegrin-mediated signaling pathway
C0007369biological_processgastrulation
C0008284biological_processpositive regulation of cell population proliferation
C0010467biological_processgene expression
C0010468biological_processregulation of gene expression
C0010558biological_processnegative regulation of macromolecule biosynthetic process
C0016020cellular_componentmembrane
C0016055biological_processWnt signaling pathway
C0016192biological_processvesicle-mediated transport
C0016477biological_processcell migration
C0016567biological_processprotein ubiquitination
C0017145biological_processstem cell division
C0030030biological_processcell projection organization
C0030163biological_processprotein catabolic process
C0030332molecular_functioncyclin binding
C0031145biological_processanaphase-promoting complex-dependent catabolic process
C0031208molecular_functionPOZ domain binding
C0031398biological_processpositive regulation of protein ubiquitination
C0031461cellular_componentcullin-RING ubiquitin ligase complex
C0031463cellular_componentCul3-RING ubiquitin ligase complex
C0031514cellular_componentmotile cilium
C0031625molecular_functionubiquitin protein ligase binding
C0031648biological_processprotein destabilization
C0031669biological_processcellular response to nutrient levels
C0032467biological_processpositive regulation of cytokinesis
C0032480biological_processnegative regulation of type I interferon production
C0032481biological_processpositive regulation of type I interferon production
C0032869biological_processcellular response to insulin stimulus
C0034198biological_processcellular response to amino acid starvation
C0034599biological_processcellular response to oxidative stress
C0035024biological_processnegative regulation of Rho protein signal transduction
C0036126cellular_componentsperm flagellum
C0040016biological_processembryonic cleavage
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043149biological_processstress fiber assembly
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0044346biological_processfibroblast apoptotic process
C0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
C0048208biological_processCOPII vesicle coating
C0051301biological_processcell division
C0051865biological_processprotein autoubiquitination
C0060337biological_processtype I interferon-mediated signaling pathway
C0061630molecular_functionubiquitin protein ligase activity
C0070062cellular_componentextracellular exosome
C0070294biological_processrenal sodium ion absorption
C0070936biological_processprotein K48-linked ubiquitination
C0071230biological_processcellular response to amino acid stimulus
C0071630biological_processnuclear protein quality control by the ubiquitin-proteasome system
C0072576biological_processliver morphogenesis
C0072686cellular_componentmitotic spindle
C0080090biological_processregulation of primary metabolic process
C0097193biological_processintrinsic apoptotic signaling pathway
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0140252biological_processregulation protein catabolic process at postsynapse
C0160072molecular_functionubiquitin ligase complex scaffold activity
C0160240biological_processRNA polymerase II transcription initiation surveillance
C1900076biological_processregulation of cellular response to insulin stimulus
C1901992biological_processpositive regulation of mitotic cell cycle phase transition
C1904262biological_processnegative regulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
D0000082biological_processG1/S transition of mitotic cell cycle
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000209biological_processprotein polyubiquitination
D0000278biological_processmitotic cell cycle
D0000902biological_processcell morphogenesis
D0000922cellular_componentspindle pole
D0001701biological_processin utero embryonic development
D0001822biological_processkidney development
D0001831biological_processtrophectodermal cellular morphogenesis
D0004842molecular_functionubiquitin-protein transferase activity
D0005112molecular_functionNotch binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005794cellular_componentGolgi apparatus
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005827cellular_componentpolar microtubule
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005929cellular_componentcilium
D0006357biological_processregulation of transcription by RNA polymerase II
D0006366biological_processtranscription by RNA polymerase II
D0006368biological_processtranscription elongation by RNA polymerase II
D0006511biological_processubiquitin-dependent protein catabolic process
D0006513biological_processprotein monoubiquitination
D0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
D0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
D0006915biological_processapoptotic process
D0006950biological_processresponse to stress
D0006954biological_processinflammatory response
D0006979biological_processresponse to oxidative stress
D0007080biological_processmitotic metaphase chromosome alignment
D0007165biological_processsignal transduction
D0007229biological_processintegrin-mediated signaling pathway
D0007369biological_processgastrulation
D0008284biological_processpositive regulation of cell population proliferation
D0010467biological_processgene expression
D0010468biological_processregulation of gene expression
D0010558biological_processnegative regulation of macromolecule biosynthetic process
D0016020cellular_componentmembrane
D0016055biological_processWnt signaling pathway
D0016192biological_processvesicle-mediated transport
D0016477biological_processcell migration
D0016567biological_processprotein ubiquitination
D0017145biological_processstem cell division
D0030030biological_processcell projection organization
D0030163biological_processprotein catabolic process
D0030332molecular_functioncyclin binding
D0031145biological_processanaphase-promoting complex-dependent catabolic process
D0031208molecular_functionPOZ domain binding
D0031398biological_processpositive regulation of protein ubiquitination
D0031461cellular_componentcullin-RING ubiquitin ligase complex
D0031463cellular_componentCul3-RING ubiquitin ligase complex
D0031514cellular_componentmotile cilium
D0031625molecular_functionubiquitin protein ligase binding
D0031648biological_processprotein destabilization
D0031669biological_processcellular response to nutrient levels
D0032467biological_processpositive regulation of cytokinesis
D0032480biological_processnegative regulation of type I interferon production
D0032481biological_processpositive regulation of type I interferon production
D0032869biological_processcellular response to insulin stimulus
D0034198biological_processcellular response to amino acid starvation
D0034599biological_processcellular response to oxidative stress
D0035024biological_processnegative regulation of Rho protein signal transduction
D0036126cellular_componentsperm flagellum
D0040016biological_processembryonic cleavage
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043149biological_processstress fiber assembly
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0044346biological_processfibroblast apoptotic process
D0045842biological_processpositive regulation of mitotic metaphase/anaphase transition
D0048208biological_processCOPII vesicle coating
D0051301biological_processcell division
D0051865biological_processprotein autoubiquitination
D0060337biological_processtype I interferon-mediated signaling pathway
D0061630molecular_functionubiquitin protein ligase activity
D0070062cellular_componentextracellular exosome
D0070294biological_processrenal sodium ion absorption
D0070936biological_processprotein K48-linked ubiquitination
D0071230biological_processcellular response to amino acid stimulus
D0071630biological_processnuclear protein quality control by the ubiquitin-proteasome system
D0072576biological_processliver morphogenesis
D0072686cellular_componentmitotic spindle
D0080090biological_processregulation of primary metabolic process
D0097193biological_processintrinsic apoptotic signaling pathway
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0140252biological_processregulation protein catabolic process at postsynapse
D0160072molecular_functionubiquitin ligase complex scaffold activity
D0160240biological_processRNA polymerase II transcription initiation surveillance
D1900076biological_processregulation of cellular response to insulin stimulus
D1901992biological_processpositive regulation of mitotic cell cycle phase transition
D1904262biological_processnegative regulation of TORC1 signaling
D1904263biological_processpositive regulation of TORC1 signaling
K0000070biological_processmitotic sister chromatid segregation
K0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
K0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005764cellular_componentlysosome
K0005813cellular_componentcentrosome
K0005819cellular_componentspindle
K0005827cellular_componentpolar microtubule
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0006511biological_processubiquitin-dependent protein catabolic process
K0006513biological_processprotein monoubiquitination
K0007094biological_processmitotic spindle assembly checkpoint signaling
K0010507biological_processnegative regulation of autophagy
K0015630cellular_componentmicrotubule cytoskeleton
K0016567biological_processprotein ubiquitination
K0030307biological_processpositive regulation of cell growth
K0031463cellular_componentCul3-RING ubiquitin ligase complex
K0031669biological_processcellular response to nutrient levels
K0032480biological_processnegative regulation of type I interferon production
K0032481biological_processpositive regulation of type I interferon production
K0034198biological_processcellular response to amino acid starvation
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0045171cellular_componentintercellular bridge
K0050868biological_processnegative regulation of T cell activation
K0050870biological_processpositive regulation of T cell activation
K0051301biological_processcell division
K0071230biological_processcellular response to amino acid stimulus
K0071233biological_processcellular response to L-leucine
K0071889molecular_function14-3-3 protein binding
K0072686cellular_componentmitotic spindle
K1904262biological_processnegative regulation of TORC1 signaling
K1904263biological_processpositive regulation of TORC1 signaling
K1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
L0000070biological_processmitotic sister chromatid segregation
L0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
L0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005764cellular_componentlysosome
L0005813cellular_componentcentrosome
L0005819cellular_componentspindle
L0005827cellular_componentpolar microtubule
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0006511biological_processubiquitin-dependent protein catabolic process
L0006513biological_processprotein monoubiquitination
L0007094biological_processmitotic spindle assembly checkpoint signaling
L0010507biological_processnegative regulation of autophagy
L0015630cellular_componentmicrotubule cytoskeleton
L0016567biological_processprotein ubiquitination
L0030307biological_processpositive regulation of cell growth
L0031463cellular_componentCul3-RING ubiquitin ligase complex
L0031669biological_processcellular response to nutrient levels
L0032480biological_processnegative regulation of type I interferon production
L0032481biological_processpositive regulation of type I interferon production
L0034198biological_processcellular response to amino acid starvation
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0045171cellular_componentintercellular bridge
L0050868biological_processnegative regulation of T cell activation
L0050870biological_processpositive regulation of T cell activation
L0051301biological_processcell division
L0071230biological_processcellular response to amino acid stimulus
L0071233biological_processcellular response to L-leucine
L0071889molecular_function14-3-3 protein binding
L0072686cellular_componentmitotic spindle
L1904262biological_processnegative regulation of TORC1 signaling
L1904263biological_processpositive regulation of TORC1 signaling
L1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkrIegLIEReYLaRtpedrkvYtYvA
ChainResidueDetails
CILE741-ALA768

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues134
DetailsDomain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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