8K6O
Structural complex of neuropeptide Y receptor 1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-2 | polymer | 355 | 40516.9 | 1 | UniProt (P04899) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 356 | 39141.8 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | D | Neuropeptide Y receptor type 1 | polymer | 341 | 39586.5 | 1 | UniProt (P25929) Pfam (PF00001) In PDB | Homo sapiens (human) | NPY1-R |
5 | S | scFV16 | polymer | 266 | 28636.8 | 1 | Mus musculus | ||
6 | E | C-flanking peptide of NPY | polymer | 36 | 4247.7 | 1 | UniProt (P01303) Pfam (PF00159) In PDB | Homo sapiens | Neuropeptide Y,CPON |
Sequence modifications
A: 1 - 355 (UniProt: P04899)
B: 2 - 340 (UniProt: P62873)
E: 1 - 36 (UniProt: P01303)
PDB | External Database | Details |
---|---|---|
Leu 5 | Val 5 | variant |
Asn 47 | Ser 47 | engineered mutation |
Ala 204 | Gly 204 | engineered mutation |
Ala 246 | Glu 246 | engineered mutation |
Ser 327 | Ala 327 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -15 | - | initiating methionine |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Leu 31 | Ile 59 | engineered mutation |
Pro 34 | Gln 62 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 159990.8 | |
All* | Total formula weight | 159990.8 |