8K50

Crystal structure of HLA-A*11:01 in complex with KRAS G12V peptide (VVVGARGVGK)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	HLA class I histocompatibility antigen, A alpha chain	polymer	276	31986.3	4	UniProt (P04439) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (human)	Human leukocyte antigen A,HLA-A
2	B, E, H, K (B, E, H, K)	Beta-2-microglobulin	polymer	122	14165.8	4	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)
3	C, F, I, L (C, F, I, L)	KRAS G12V peptide (VVVGAVGVGK)	polymer	10	885.1	4	UniProt (P01116)	Homo sapiens (human)

Sequence modifications

A, D, G, J: 25 - 299 (UniProt: P04439)

PDB	External Database	Details
Met 24	-	initiating methionine
Tyr 33	Phe 33	variant
Asp 114	Ala 114	variant
Pro 129	Ser 129	variant

B, E, H, K: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 100	-	expression tag
Ser 101	-	expression tag
Gly 102	-	expression tag
Gly 103	-	expression tag
Ser 104	-	expression tag
Gly 105	-	expression tag
Ala 106	-	expression tag
Gly 107	-	expression tag
Leu 108	-	expression tag
Asn 109	-	expression tag
Asp 110	-	expression tag
Ile 111	-	expression tag
Phe 112	-	expression tag
Glu 113	-	expression tag
Ala 114	-	expression tag
Gln 115	-	expression tag
Lys 116	-	expression tag
Ile 117	-	expression tag
Glu 118	-	expression tag
Trp 119	-	expression tag
His 120	-	expression tag
Glu 121	-	expression tag

C, F, I, L: 1 - 10 (UniProt: P01116)

PDB	External Database	Details
Val 6	Gly 12	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	188148.4
All*	Total formula weight	188148.4

*Water molecules are not included.