8K4O
Cryo-EM structure of Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor (KSHV-GPCR)in complex with CXC chemokine CXCL1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | G protein-coupled receptor | polymer | 333 | 37881.8 | 1 | UniProt (Q76SF8) Pfam (PF00001) UniProt (by SIFTS) (Q98146) | Human gammaherpesvirus 8 | |
| 2 | B (F) | Growth-regulated alpha protein | polymer | 63 | 6727.9 | 1 | UniProt (P09341) Pfam (PF00048) | Homo sapiens (human) | C-X-C motif chemokine 1,GRO-alpha(1-73),Melanoma growth stimulatory activity,MGSA,Neutrophil-activating protein 3,NAP-3 |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 336 | 36956.4 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (C) | Guanine nucleotide-binding protein G(I) subunit alpha-1 | polymer | 350 | 39914.4 | 1 | UniProt (A0A6P3VR35) Pfam (PF00503) UniProt (by SIFTS) (P63096) | Homo sapiens (human) | |
| 5 | E (G) | Guanine nucleotide-binding protein subunit gamma | polymer | 54 | 6002.0 | 1 | UniProt (A0A663LQV7) Pfam (PF00631) UniProt (by SIFTS) (P59768) | Homo sapiens (human) |
Sequence modifications
C: 5 - 354 (UniProt: A0A6P3VR35)
| PDB | External Database | Details |
|---|---|---|
| Ala 7 | Thr 7 | conflict |
| Glu 25 | Asp 25 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 127482.5 | |
| All* | Total formula weight | 127482.5 |
