8K2X
CXCR3-DNGi complex activated by CXCL10
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40445.1 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 384 | 42005.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | R | Soluble cytochrome b562,C-X-C chemokine receptor type 3,Oplophorus-luciferin 2-monooxygenase catalytic subunit | polymer | 657 | 72918.0 | 1 | UniProt (P0ABE7) UniProt (P49682) UniProt (Q9GV45) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,CXC-R3,CXCR-3,CKR-L2,G protein-coupled receptor 9,Interferon-inducible protein 10 receptor,IP-10 receptor,19kOLase |
5 | S | single-chain variable fragment scFv16 | polymer | 259 | 27784.9 | 1 | Oplophorus gracilirostris (Luminous shrimp) | ||
6 | L | C-X-C motif chemokine 10 | polymer | 98 | 10898.1 | 1 | UniProt (P02778) Pfam (PF00048) In PDB | Homo sapiens (human) | 10 kDa interferon gamma-induced protein,Gamma-IP10,IP-10,Small-inducible cytokine B10 |
7 | R | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
R: -111 - -7 (UniProt: P0ABE7)
R: 1 - 361 (UniProt: P49682)
R: 362 - 519 (UniProt: Q9GV45)
PDB | External Database | Details |
---|---|---|
Ala 203 | Gly 203 | conflict |
Ser 326 | Ala 326 | conflict |
PDB | External Database | Details |
---|---|---|
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Gly 341 | - | expression tag |
Ala 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Ala 345 | - | expression tag |
Ser 346 | - | expression tag |
Gly 347 | - | expression tag |
Ala 348 | - | expression tag |
Ser 349 | - | expression tag |
Gly 350 | - | expression tag |
Ala 351 | - | expression tag |
Ser 352 | - | expression tag |
Val 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Trp 356 | - | expression tag |
Arg 357 | - | expression tag |
Leu 358 | - | expression tag |
Phe 359 | - | expression tag |
Lys 360 | - | expression tag |
Lys 361 | - | expression tag |
Ile 362 | - | expression tag |
Ser 363 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -137 | - | initiating methionine |
Lys -136 | - | expression tag |
Thr -135 | - | expression tag |
Ile -134 | - | expression tag |
Ile -133 | - | expression tag |
Ala -132 | - | expression tag |
Leu -131 | - | expression tag |
Ser -130 | - | expression tag |
Tyr -129 | - | expression tag |
Ile -128 | - | expression tag |
Phe -127 | - | expression tag |
Cys -126 | - | expression tag |
Leu -125 | - | expression tag |
Val -124 | - | expression tag |
Phe -123 | - | expression tag |
Ala -122 | - | expression tag |
Asp -121 | - | expression tag |
Tyr -120 | - | expression tag |
Lys -119 | - | expression tag |
Asp -118 | - | expression tag |
Asp -117 | - | expression tag |
Asp -116 | - | expression tag |
Asp -115 | - | expression tag |
Lys -114 | - | expression tag |
Gly -113 | - | expression tag |
Ser -112 | - | expression tag |
Trp -105 | Met 29 | conflict |
Ile -10 | His 124 | conflict |
Leu -6 | - | linker |
Leu -5 | - | linker |
Val -4 | - | linker |
Pro -3 | - | linker |
Arg -2 | - | linker |
Gly -1 | - | linker |
Ser 0 | - | linker |
R: 362 - 519 (UniProt: Q9GV45)
PDB | External Database | Details |
---|---|---|
Val 362 | Thr 27 | conflict |
Glu 366 | Ala 31 | conflict |
Glu 373 | Gln 38 | conflict |
Ala 377 | Gly 42 | conflict |
Leu 380 | Gln 45 | conflict |
Val 389 | Leu 54 | conflict |
Leu 393 | Phe 58 | conflict |
Asn 395 | Ala 60 | conflict |
Ala 397 | Gly 62 | conflict |
Arg 405 | Lys 70 | conflict |
Ile 406 | Val 71 | conflict |
Arg 408 | Leu 73 | conflict |
Ala 413 | Gly 78 | conflict |
Ile 416 | Ala 81 | conflict |
Ala 429 | Gly 94 | conflict |
Asp 430 | Phe 95 | conflict |
Ala 433 | Gly 98 | conflict |
Gln 434 | Leu 99 | conflict |
Glu 437 | Met 102 | conflict |
Val 438 | Ile 103 | conflict |
Val 452 | Ile 117 | conflict |
Pro 455 | His 120 | conflict |
Leu 469 | Ile 134 | conflict |
Asn 470 | Asp 135 | conflict |
Glu 477 | Pro 142 | conflict |
Lys 486 | Gln 151 | conflict |
Ile 500 | Tyr 165 | conflict |
Thr 506 | Asn 171 | conflict |
Met 511 | Leu 176 | conflict |
Ser 519 | Gly 184 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 201913.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 386.7 | |
All* | Total formula weight | 202299.7 |