8K2X
CXCR3-DNGi complex activated by CXCL10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40445.1 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 384 | 42005.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (R) | Soluble cytochrome b562,C-X-C chemokine receptor type 3,Oplophorus-luciferin 2-monooxygenase catalytic subunit | polymer | 657 | 72918.0 | 1 | UniProt (P0ABE7) UniProt (P49682) UniProt (Q9GV45) Pfam (PF07361) Pfam (PF00001) | Escherichia coli | Cytochrome b-562,CXC-R3,CXCR-3,CKR-L2,G protein-coupled receptor 9,Interferon-inducible protein 10 receptor,IP-10 receptor,19kOLase |
| 5 | E (S) | single-chain variable fragment scFv16 | polymer | 259 | 27784.9 | 1 | Oplophorus gracilirostris (Luminous shrimp) | ||
| 6 | F (L) | C-X-C motif chemokine 10 | polymer | 98 | 10898.1 | 1 | UniProt (P02778) Pfam (PF00048) | Homo sapiens (human) | 10 kDa interferon gamma-induced protein,Gamma-IP10,IP-10,Small-inducible cytokine B10 |
| 7 | G (R) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
R: -111 - -7 (UniProt: P0ABE7)
R: 1 - 361 (UniProt: P49682)
R: 362 - 519 (UniProt: Q9GV45)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | conflict |
| Ser 326 | Ala 326 | conflict |
| PDB | External Database | Details |
|---|---|---|
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ala 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Ala 345 | - | expression tag |
| Ser 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ala 348 | - | expression tag |
| Ser 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Ala 351 | - | expression tag |
| Ser 352 | - | expression tag |
| Val 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Trp 356 | - | expression tag |
| Arg 357 | - | expression tag |
| Leu 358 | - | expression tag |
| Phe 359 | - | expression tag |
| Lys 360 | - | expression tag |
| Lys 361 | - | expression tag |
| Ile 362 | - | expression tag |
| Ser 363 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -137 | - | initiating methionine |
| Lys -136 | - | expression tag |
| Thr -135 | - | expression tag |
| Ile -134 | - | expression tag |
| Ile -133 | - | expression tag |
| Ala -132 | - | expression tag |
| Leu -131 | - | expression tag |
| Ser -130 | - | expression tag |
| Tyr -129 | - | expression tag |
| Ile -128 | - | expression tag |
| Phe -127 | - | expression tag |
| Cys -126 | - | expression tag |
| Leu -125 | - | expression tag |
| Val -124 | - | expression tag |
| Phe -123 | - | expression tag |
| Ala -122 | - | expression tag |
| Asp -121 | - | expression tag |
| Tyr -120 | - | expression tag |
| Lys -119 | - | expression tag |
| Asp -118 | - | expression tag |
| Asp -117 | - | expression tag |
| Asp -116 | - | expression tag |
| Asp -115 | - | expression tag |
| Lys -114 | - | expression tag |
| Gly -113 | - | expression tag |
| Ser -112 | - | expression tag |
| Trp -105 | Met 29 | conflict |
| Ile -10 | His 124 | conflict |
| Leu -6 | - | linker |
| Leu -5 | - | linker |
| Val -4 | - | linker |
| Pro -3 | - | linker |
| Arg -2 | - | linker |
| Gly -1 | - | linker |
| Ser 0 | - | linker |
R: 362 - 519 (UniProt: Q9GV45)
| PDB | External Database | Details |
|---|---|---|
| Val 362 | Thr 27 | conflict |
| Glu 366 | Ala 31 | conflict |
| Glu 373 | Gln 38 | conflict |
| Ala 377 | Gly 42 | conflict |
| Leu 380 | Gln 45 | conflict |
| Val 389 | Leu 54 | conflict |
| Leu 393 | Phe 58 | conflict |
| Asn 395 | Ala 60 | conflict |
| Ala 397 | Gly 62 | conflict |
| Arg 405 | Lys 70 | conflict |
| Ile 406 | Val 71 | conflict |
| Arg 408 | Leu 73 | conflict |
| Ala 413 | Gly 78 | conflict |
| Ile 416 | Ala 81 | conflict |
| Ala 429 | Gly 94 | conflict |
| Asp 430 | Phe 95 | conflict |
| Ala 433 | Gly 98 | conflict |
| Gln 434 | Leu 99 | conflict |
| Glu 437 | Met 102 | conflict |
| Val 438 | Ile 103 | conflict |
| Val 452 | Ile 117 | conflict |
| Pro 455 | His 120 | conflict |
| Leu 469 | Ile 134 | conflict |
| Asn 470 | Asp 135 | conflict |
| Glu 477 | Pro 142 | conflict |
| Lys 486 | Gln 151 | conflict |
| Ile 500 | Tyr 165 | conflict |
| Thr 506 | Asn 171 | conflict |
| Met 511 | Leu 176 | conflict |
| Ser 519 | Gly 184 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 201913.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.7 | |
| All* | Total formula weight | 202299.7 |
