8K2W
Structure of CXCR3 complexed with antagonist AMG487
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | N | Nb6 | polymer | 169 | 18665.9 | 1 | Lama glama | ||
| 2 | R | Soluble cytochrome b562,C-X-C chemokine receptor type 3,Kappa-type opioid receptor | polymer | 507 | 56327.1 | 1 | UniProt (P0ABE7) UniProt (P49682) UniProt (P41145) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,K-OR-1,KOR-1 |
| 3 | R | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 4 | R | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 1 | Chemie (PCW) | |||
| 5 | R | [1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE | non-polymer | 468.6 | 1 | Chemie (LPC) | |||
| 6 | R | N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxidanylidene-pyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethyloxy)phenyl]ethanamide | non-polymer | 603.6 | 1 | Chemie (FI6) |
Sequence modifications
R: -111 - -7 (UniProt: P0ABE7)
R: 1 - 240 (UniProt: P49682)
R: 241 - 262 (UniProt: P41145)
R: 263 - 369 (UniProt: P49682)
| PDB | External Database | Details |
|---|---|---|
| Met -137 | - | initiating methionine |
| Lys -136 | - | expression tag |
| Thr -135 | - | expression tag |
| Ile -134 | - | expression tag |
| Ile -133 | - | expression tag |
| Ala -132 | - | expression tag |
| Leu -131 | - | expression tag |
| Ser -130 | - | expression tag |
| Tyr -129 | - | expression tag |
| Ile -128 | - | expression tag |
| Phe -127 | - | expression tag |
| Cys -126 | - | expression tag |
| Leu -125 | - | expression tag |
| Val -124 | - | expression tag |
| Phe -123 | - | expression tag |
| Ala -122 | - | expression tag |
| Asp -121 | - | expression tag |
| Tyr -120 | - | expression tag |
| Lys -119 | - | expression tag |
| Asp -118 | - | expression tag |
| Asp -117 | - | expression tag |
| Asp -116 | - | expression tag |
| Asp -115 | - | expression tag |
| Lys -114 | - | expression tag |
| Gly -113 | - | expression tag |
| Ser -112 | - | expression tag |
| Trp -105 | Met 29 | conflict |
| Ile -10 | His 124 | conflict |
| Leu -6 | - | linker |
| Leu -5 | - | linker |
| Val -4 | - | linker |
| Pro -3 | - | linker |
| Arg -2 | - | linker |
| Gly -1 | - | linker |
| Ser 0 | - | linker |
R: 241 - 262 (UniProt: P41145)
R: 263 - 369 (UniProt: P49682)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74993.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2246.0 | |
| All* | Total formula weight | 77238.9 |
