8JWO

Crystal structure of AKRtyl-tylosin complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Aldo/keto reductase	polymer	351	38465.1	16	UniProt (A0A3R7J519) Pfam (PF00248)	Streptomyces xinghaiensis
2	AA, BA, CA, DA, EA... (K, L, M, N, O...)	TYLOSIN	non-polymer		916.1	16	Chemie (TYK) PubChem (16757852) PubChem (22836652) PubChem (23277825) PubChem (24870678) PubChem (16220036) PubChem (17991072) PubChem (22836651) PubChem (45357419) PubChem (53384933) PubChem (59094949) PubChem (59661904) PubChem (439504) PubChem (71401278) PubChem (77845066) PubChem (89291189) PubChem (90919693) PubChem (5062352) PubChem (5280440) PubChem (5284478) PubChem (101000161) PubChem (117717254) PubChem (6260974) PubChem (118253183) PubChem (6426701) PubChem (6433273) PubChem (6474983) PubChem (121595924) PubChem (66509091) PubChem (123431711) PubChem (123876866) PubChem (124762423) PubChem (125418992) PubChem (126684001) PubChem (129606990) PubChem (129637441) PubChem (130456170) PubChem (131664241) PubChem (11355011) PubChem (134555958) PubChem (135391181) PubChem (73440817) PubChem (12080500) PubChem (12873467) PubChem (12873460) PubChem (137704920) PubChem (137698429) PubChem (137968077) PubChem (14961) PubChem (140327476) PubChem (145875201) PubChem (91254232) PubChem (163001679) PubChem (163199054) PubChem (166639057) PubChem (168312033) PubChem (168314097) PubChem (168499119) PubChem (122130540) PubChem (172400043) PubChem (122173023) PubChem (173736491) PubChem (175675632) PubChem (124708603) PubChem (124762421) PubChem (124762422) PubChem (124762424) PubChem (125418989) PubChem (125418991) PubChem (125418994) PubChem (6540438) PubChem (6540691) PubChem (129010288) PubChem (6857849) PubChem (130456245) PubChem (131664323) PubChem (131847714) PubChem (133109136) PubChem (133124925) PubChem (134129704) PubChem (134693945) PubChem (135815438) PubChem (137704868) PubChem (138991585) PubChem (145864867) PubChem (12873441) PubChem (153491968) PubChem (154825567) PubChem (163001680)
3	GA, HA, IA, JA, KA... (A, B, C, D, E...)	water	water		18.0	2147	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P: 1 - 331 (UniProt: A0A3R7J519)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	615441.2
Non-Polymers*	Number of molecules	16
	Total formula weight	14657.6
All*	Total formula weight	630098.8

*Water molecules are not included.