8JVA
Cryo-EM structure of the N-terminal domain of Omicron BA.1 in complex with nanobody N235 and S2L20 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | nanobody N235 | polymer | 126 | 13970.4 | 1 | Vicugna pacos | ||
| 2 | B (A) | S2L20 light chain | polymer | 236 | 26018.0 | 1 | Homo sapiens (human) | ||
| 3 | C (B) | S2L20 heavy chain | polymer | 473 | 52041.5 | 1 | Homo sapiens (human) | ||
| 4 | D (F) | Spike protein S2' | polymer | 300 | 34076.6 | 1 | UniProt (P0DTC2) Pfam (PF16451) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | |
| 5 | E, F, G, H, I (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) |
Sequence modifications
F: 1 - 303 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Val 67 | Ala 67 | variant |
| - | His 69 | deletion |
| - | Val 70 | deletion |
| Ile 95 | Thr 95 | variant |
| - | Gly 142 | deletion |
| - | Val 143 | deletion |
| - | Tyr 144 | deletion |
| Asp 145 | Tyr 145 | variant |
| - | Asn 211 | deletion |
| Ile 210 | Leu 212 | variant |
| Glu 212 | - | insertion |
| Pro 213 | - | insertion |
| Glu 214 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 126106.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1106.0 | |
| All* | Total formula weight | 127212.6 |
