8JV7
Cryo-EM structure of the panda P2X7 receptor in complex with PPADS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | P2X purinoceptor | polymer | 342 | 38716.2 | 3 | UniProt (D2GVW0) Pfam (PF00864) UniProt (by SIFTS) (G1M6C4) | Ailuropoda melanoleuca (giant panda) | |
| 2 | D, E, G, H, J... (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 3 | F, I, L (A, B, C) | 4-[(E)-[4-methanoyl-6-methyl-5-oxidanyl-3-(phosphonooxymethyl)pyridin-2-yl]diazenyl]benzene-1,3-disulfonic acid | non-polymer | 511.4 | 3 | Chemie (UO6) | |||
| 4 | M, N, O (A, B, C) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B, C: 23 - 359 (UniProt: D2GVW0)
| PDB | External Database | Details |
|---|---|---|
| Gly 21 | - | expression tag |
| Ser 22 | - | expression tag |
| Ala 35 | Val 35 | engineered mutation |
| Ala 125 | Arg 125 | engineered mutation |
| Lys 174 | Glu 174 | engineered mutation |
| Ser 241 | Asn 241 | engineered mutation |
| Ser 284 | Asn 284 | engineered mutation |
| Ala 360 | - | expression tag |
| Ser 361 | - | expression tag |
| Ser 362 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 116148.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2861.4 | |
| All* | Total formula weight | 119010.1 |
