8JT6
5-HT1A-Gi in complex with compound (R)-IHCH-7179
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
3 | E | ScFv16 | polymer | 269 | 28813.0 | 1 | Mus musculus (house mouse) | ||
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 67 | 7432.6 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | R | Soluble cytochrome b562,5-hydroxytryptamine receptor 1A | polymer | 544 | 60539.7 | 1 | UniProt (P0ABE7) UniProt (P08908) Pfam (PF07361) Pfam (PF00001) In PDB | Escherichia coli | Cytochrome b-562,5-HT-1A,5-HT1A,G-21,Serotonin receptor 1A |
6 | R | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) | |||
7 | R | PALMITIC ACID | non-polymer | 256.4 | 2 | Chemie (PLM) | |||
8 | R | [(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate | non-polymer | 854.9 | 1 | Chemie (J40) | |||
9 | R | 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one | non-polymer | 377.5 | 1 | Chemie (EZX) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
R: -92 - 12 (UniProt: P0ABE7)
R: 22 - 422 (UniProt: P08908)
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | conflict |
Ala 203 | Gly 203 | conflict |
Ala 245 | Glu 245 | conflict |
Ser 326 | Ala 326 | conflict |
PDB | External Database | Details |
---|---|---|
Met -4 | - | initiating methionine |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -121 | - | initiating methionine |
Asp -120 | - | expression tag |
Tyr -119 | - | expression tag |
Lys -118 | - | expression tag |
Asp -117 | - | expression tag |
Asp -116 | - | expression tag |
Asp -115 | - | expression tag |
Asp -114 | - | expression tag |
Ala -113 | - | expression tag |
Lys -112 | - | expression tag |
Leu -111 | - | expression tag |
Gln -110 | - | expression tag |
Thr -109 | - | expression tag |
Met -108 | - | expression tag |
His -107 | - | expression tag |
His -106 | - | expression tag |
His -105 | - | expression tag |
His -104 | - | expression tag |
His -103 | - | expression tag |
His -102 | - | expression tag |
His -101 | - | expression tag |
His -100 | - | expression tag |
His -99 | - | expression tag |
His -98 | - | expression tag |
His -97 | - | expression tag |
His -96 | - | expression tag |
His -95 | - | expression tag |
His -94 | - | expression tag |
His -93 | - | expression tag |
Trp -86 | Met 29 | conflict |
Ile 9 | His 124 | conflict |
Leu 13 | - | linker |
Ala 14 | - | linker |
Ser 15 | - | linker |
Glu 16 | - | linker |
Asn 17 | - | linker |
Leu 18 | - | linker |
Tyr 19 | - | linker |
Phe 20 | - | linker |
Gln 21 | - | linker |
PDB | External Database | Details |
---|---|---|
Thr 24 | Asn 24 | conflict |
Trp 125 | Leu 125 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 175114.9 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 3678.5 | |
All* | Total formula weight | 178793.3 |