8JSP
Ulotaront(SEP-363856)-bound Serotonin 1A (5-HT1A) receptor-Gi complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 351 | 40122.7 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 328 | 35985.4 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
| 3 | E | ScFv16 | polymer | 250 | 26594.7 | 1 | Mus musculus | ||
| 4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 45 | 4990.8 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 5 | R | 5-hydroxytryptamine receptor 1A | polymer | 381 | 42001.1 | 1 | UniProt (P08908) Pfam (PF00001) In PDB | Homo sapiens (human) | 5-HT-1A,5-HT1A,G-21,Serotonin receptor 1A |
| 6 | R | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine | non-polymer | 183.3 | 1 | Chemie (UJL) |
Sequence modifications
A: 4 - 354 (UniProt: P63096)
R: 35 - 415 (UniProt: P08908)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | engineered mutation |
| Ala 203 | Gly 203 | engineered mutation |
| Ala 245 | Glu 245 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 125 | Leu 125 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 149694.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 183.3 | |
| All* | Total formula weight | 149877.9 |
