8JRU
Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor | polymer | 478 | 54307.1 | 1 | UniProt (P03435) UniProt (P04070) UniProt (P47871) UniProt (P30518) Pfam (PF02793) Pfam (PF00002) In PDB | Influenza A virus (strain A/Victoria/3/1975 H3N2) | GL-R,V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor |
2 | A, H, L | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30) | polymer | 627 | 69173.9 | 3 | Pfam (PF00339) Pfam (PF02752) UniProt (by SIFTS) (P17870) In PDB | Bos taurus | |
3 | B | Nanobody 32 | polymer | 126 | 13867.4 | 1 | Escherichia phage EcSzw-2 | ||
4 | A | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 1 | Chemie (PIO) |
Sequence modifications
R: -14 - 1 (UniProt: P03435)
R: 5 - 16 (UniProt: P04070)
R: 27 - 1342 (UniProt: P47871)
R: 1343 - 1371 (UniProt: P30518)
PDB | External Database | Details |
---|---|---|
Gly -16 | - | expression tag |
Ser -15 | - | expression tag |
Gly 2 | - | linker |
Ala 3 | - | linker |
Pro 4 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 17 | - | linker |
Ser 18 | - | linker |
Gly 19 | - | linker |
Ser 20 | - | linker |
Ala 21 | - | linker |
Gly 22 | - | linker |
Ser 23 | - | linker |
Ala 24 | - | linker |
Gly 25 | - | linker |
Ser 26 | - | linker |
R: 1343 - 1371 (UniProt: P30518)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 275696.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 746.6 | |
All* | Total formula weight | 276442.8 |