8JRR
Structure of E6AP-E6 complex in Det2 state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Ubiquitin-protein ligase E3A | polymer | 875 | 100705.4 | 2 | UniProt (Q05086) Pfam (PF16558) Pfam (PF00632) | Homo sapiens (human) | E6AP ubiquitin-protein ligase,HECT-type ubiquitin transferase E3A,Human papillomavirus E6-associated protein,Oncogenic protein-associated protein E6-AP,Renal carcinoma antigen NY-REN-54 |
| 2 | B, D (B, D) | Protein E6 | polymer | 135 | 16316.9 | 2 | UniProt (P03126) Pfam (PF00518) | Human papillomavirus 16 | |
| 3 | E, F, G, H (B, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
A, C: 1 - 875 (UniProt: Q05086)
B, D: 12 - 146 (UniProt: P03126)
| PDB | External Database | Details |
|---|---|---|
| Ala 798 | Thr 798 | engineered mutation |
| Ala 799 | Asp 799 | engineered mutation |
| Ala 843 | Cys 843 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 87 | Cys 87 | engineered mutation |
| Ser 104 | Cys 104 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 234044.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 234306.3 |
