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8JRR

Structure of E6AP-E6 complex in Det2 state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0000502cellular_componentproteasome complex
A0001541biological_processovarian follicle development
A0003713molecular_functiontranscription coactivator activity
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006511biological_processubiquitin-dependent protein catabolic process
A0007420biological_processbrain development
A0016567biological_processprotein ubiquitination
A0016740molecular_functiontransferase activity
A0030521biological_processandrogen receptor signaling pathway
A0031398biological_processpositive regulation of protein ubiquitination
A0032570biological_processresponse to progesterone
A0035037biological_processsperm entry
A0035641biological_processlocomotory exploration behavior
A0042220biological_processresponse to cocaine
A0042542biological_processresponse to hydrogen peroxide
A0042752biological_processregulation of circadian rhythm
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0048167biological_processregulation of synaptic plasticity
A0048511biological_processrhythmic process
A0050804biological_processmodulation of chemical synaptic transmission
A0050847biological_processprogesterone receptor signaling pathway
A0051865biological_processprotein autoubiquitination
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060736biological_processprostate gland growth
A0061002biological_processnegative regulation of dendritic spine morphogenesis
A0061630molecular_functionubiquitin protein ligase activity
A0061743biological_processmotor learning
A0070936biological_processprotein K48-linked ubiquitination
A0098978cellular_componentglutamatergic synapse
A1904262biological_processnegative regulation of TORC1 signaling
A1905528biological_processpositive regulation of Golgi lumen acidification
A1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
A2000058biological_processregulation of ubiquitin-dependent protein catabolic process
C0000209biological_processprotein polyubiquitination
C0000502cellular_componentproteasome complex
C0001541biological_processovarian follicle development
C0003713molecular_functiontranscription coactivator activity
C0004842molecular_functionubiquitin-protein transferase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006508biological_processproteolysis
C0006511biological_processubiquitin-dependent protein catabolic process
C0007420biological_processbrain development
C0016567biological_processprotein ubiquitination
C0016740molecular_functiontransferase activity
C0030521biological_processandrogen receptor signaling pathway
C0031398biological_processpositive regulation of protein ubiquitination
C0032570biological_processresponse to progesterone
C0035037biological_processsperm entry
C0035641biological_processlocomotory exploration behavior
C0042220biological_processresponse to cocaine
C0042542biological_processresponse to hydrogen peroxide
C0042752biological_processregulation of circadian rhythm
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046872molecular_functionmetal ion binding
C0048167biological_processregulation of synaptic plasticity
C0048511biological_processrhythmic process
C0050804biological_processmodulation of chemical synaptic transmission
C0050847biological_processprogesterone receptor signaling pathway
C0051865biological_processprotein autoubiquitination
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0060736biological_processprostate gland growth
C0061002biological_processnegative regulation of dendritic spine morphogenesis
C0061630molecular_functionubiquitin protein ligase activity
C0061743biological_processmotor learning
C0070936biological_processprotein K48-linked ubiquitination
C0098978cellular_componentglutamatergic synapse
C1904262biological_processnegative regulation of TORC1 signaling
C1905528biological_processpositive regulation of Golgi lumen acidification
C1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
C2000058biological_processregulation of ubiquitin-dependent protein catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues144
DetailsZN_FING: ZN_FING => ECO:0000255|HAMAP-Rule:MF_04006
ChainResidueDetails
BCYS37-CYS73
BCYS110-CYS146
DCYS37-CYS73
DCYS110-CYS146

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Glycyl thioester intermediate
ChainResidueDetails
AALA843
CALA843

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER218
CSER218

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269|PubMed:23581475
ChainResidueDetails
ATYR659
CTYR659

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 438
ChainResidueDetails
AARG529unknown
AGLU562unknown
AGLU573unknown
AASP630electrostatic stabiliser
AHIS841
AALA843covalent catalysis

site_idMCSA2
Number of Residues6
DetailsM-CSA 438
ChainResidueDetails
CARG529unknown
CGLU562unknown
CGLU573unknown
CASP630electrostatic stabiliser
CHIS841
CALA843covalent catalysis

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PDB entries from 2024-07-10

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