8JLH

Cryo-EM structure of SV2A dimer in complex with BoNT/A2 Hc and levetiracetam

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Synaptic vesicle glycoprotein 2A	polymer	750	83774.0	2	UniProt (Q7L0J3) Pfam (PF00083) In PDB	Homo sapiens (human)
2	B, D	Botulinum neurotoxin	polymer	426	49456.2	2	UniProt (D2KCK3) Pfam (PF07953) Pfam (PF07951) In PDB	Clostridium botulinum
3	E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
4	A	(2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide	non-polymer		170.2	1	Chemie (UKX)
5	A, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, C: 2 - 742 (UniProt: Q7L0J3)

PDB	External Database	Details
Met -7	-	initiating methionine
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	266460.4
Branched	Number of molecules	2
	Total formula weight	1141.1
Non-Polymers*	Number of molecules	5
	Total formula weight	1055.0
All*	Total formula weight	268656.5

*Water molecules are not included.