8JLH

Cryo-EM structure of SV2A dimer in complex with BoNT/A2 Hc and levetiracetam

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0005911	cellular_component	cell-cell junction
A	0006836	biological_process	neurotransmitter transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0007268	biological_process	chemical synaptic transmission
A	0008021	cellular_component	synaptic vesicle
A	0016020	cellular_component	membrane
A	0016082	biological_process	synaptic vesicle priming
A	0019901	molecular_function	protein kinase binding
A	0022857	molecular_function	transmembrane transporter activity
A	0030672	cellular_component	synaptic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031594	cellular_component	neuromuscular junction
A	0043005	cellular_component	neuron projection
A	0048786	cellular_component	presynaptic active zone
A	0055085	biological_process	transmembrane transport
A	0098793	cellular_component	presynapse
A	0098978	cellular_component	glutamatergic synapse
A	0098982	cellular_component	GABA-ergic synapse
B	0005576	cellular_component	extracellular region
C	0005783	cellular_component	endoplasmic reticulum
C	0005886	cellular_component	plasma membrane
C	0005911	cellular_component	cell-cell junction
C	0006836	biological_process	neurotransmitter transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0007268	biological_process	chemical synaptic transmission
C	0008021	cellular_component	synaptic vesicle
C	0016020	cellular_component	membrane
C	0016082	biological_process	synaptic vesicle priming
C	0019901	molecular_function	protein kinase binding
C	0022857	molecular_function	transmembrane transporter activity
C	0030672	cellular_component	synaptic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0031594	cellular_component	neuromuscular junction
C	0043005	cellular_component	neuron projection
C	0048786	cellular_component	presynaptic active zone
C	0055085	biological_process	transmembrane transport
C	0098793	cellular_component	presynapse
C	0098978	cellular_component	glutamatergic synapse
C	0098982	cellular_component	GABA-ergic synapse
D	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00217
Number of Residues	26
Details	SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. LsGVGiGGsipivfsYfsEflaqekR

Chain	Residue	Details
A	LEU264-ARG289

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	174
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q02563","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9JIS5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Motif: {"description":"Host ganglioside-binding motif","evidences":[{"source":"UniProtKB","id":"P0DPI0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---