8JKM

RN-1747 bound state of mTRPV4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transient receptor potential cation channel subfamily V member 4	polymer	700	79611.7	4	UniProt (Q9EPK8) Pfam (PF00023) Pfam (PF00520)	Mus musculus (house mouse)	TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,Vanilloid receptor-related osmotically-activated channel,VR-OAC

Sequence modifications

A, B, C, D: 137 - 801 (UniProt: Q9EPK8)

PDB	External Database	Details
Asp 102	-	expression tag
Tyr 103	-	expression tag
Lys 104	-	expression tag
Asp 105	-	expression tag
Asp 106	-	expression tag
Asp 107	-	expression tag
Asp 108	-	expression tag
Lys 109	-	expression tag
Trp 110	-	expression tag
Ser 111	-	expression tag
His 112	-	expression tag
Pro 113	-	expression tag
Gln 114	-	expression tag
Phe 115	-	expression tag
Glu 116	-	expression tag
Lys 117	-	expression tag
Gly 118	-	expression tag
Gly 119	-	expression tag
Gly 120	-	expression tag
Gly 121	-	expression tag
Ser 122	-	expression tag
Gly 123	-	expression tag
Gly 124	-	expression tag
Ser 125	-	expression tag
Ala 126	-	expression tag
Trp 127	-	expression tag
Ser 128	-	expression tag
His 129	-	expression tag
Pro 130	-	expression tag
Gln 131	-	expression tag
Phe 132	-	expression tag
Glu 133	-	expression tag
Lys 134	-	expression tag
Glu 135	-	expression tag
Phe 136	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	318446.7
All*	Total formula weight	318446.7

*Water molecules are not included.