8JKM
RN-1747 bound state of mTRPV4
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0055085 | biological_process | transmembrane transport |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0055085 | biological_process | transmembrane transport |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0055085 | biological_process | transmembrane transport |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 564 |
Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | SER470-TYR490 | |
B | ALA573-THR593 | |
B | ILE609-LEU636 | |
B | VAL694-VAL722 | |
C | SER470-TYR490 | |
C | TYR508-THR534 | |
C | SER548-LEU568 | |
C | ALA573-THR593 | |
C | ILE609-LEU636 | |
C | VAL694-VAL722 | |
D | SER470-TYR490 | |
A | TYR508-THR534 | |
D | TYR508-THR534 | |
D | SER548-LEU568 | |
D | ALA573-THR593 | |
D | ILE609-LEU636 | |
D | VAL694-VAL722 | |
A | SER548-LEU568 | |
A | ALA573-THR593 | |
A | ILE609-LEU636 | |
A | VAL694-VAL722 | |
B | SER470-TYR490 | |
B | TYR508-THR534 | |
B | SER548-LEU568 |
site_id | SWS_FT_FI2 |
Number of Residues | 216 |
Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | TYR491-ASP507 | |
C | ALA569-GLU572 | |
C | ASN637-THR665 | |
C | LEU686-VAL693 | |
D | TYR491-ASP507 | |
D | ALA569-GLU572 | |
D | ASN637-THR665 | |
D | LEU686-VAL693 | |
A | ALA569-GLU572 | |
A | ASN637-THR665 | |
A | LEU686-VAL693 | |
B | TYR491-ASP507 | |
B | ALA569-GLU572 | |
B | ASN637-THR665 | |
B | LEU686-VAL693 | |
C | TYR491-ASP507 |
site_id | SWS_FT_FI3 |
Number of Residues | 104 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | LYS535-GLY547 | |
A | ARG594-LYS608 | |
B | LYS535-GLY547 | |
B | ARG594-LYS608 | |
C | LYS535-GLY547 | |
C | ARG594-LYS608 | |
D | LYS535-GLY547 | |
D | ARG594-LYS608 |
site_id | SWS_FT_FI4 |
Number of Residues | 76 |
Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:O35433 |
Chain | Residue | Details |
A | PHE666-MET685 | |
B | PHE666-MET685 | |
C | PHE666-MET685 | |
D | PHE666-MET685 |
site_id | SWS_FT_FI5 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9HBA0 |
Chain | Residue | Details |
A | LYS192 | |
B | ARG248 | |
C | LYS192 | |
C | LYS197 | |
C | ASN201 | |
C | TYR236 | |
C | ARG248 | |
D | LYS192 | |
D | LYS197 | |
D | ASN201 | |
D | TYR236 | |
A | LYS197 | |
D | ARG248 | |
A | ASN201 | |
A | TYR236 | |
A | ARG248 | |
B | LYS192 | |
B | LYS197 | |
B | ASN201 | |
B | TYR236 |
site_id | SWS_FT_FI6 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:A0A1D5PXA5 |
Chain | Residue | Details |
A | ARG249 | |
D | ARG249 | |
D | ASN296 | |
D | LYS344 | |
A | ASN296 | |
A | LYS344 | |
B | ARG249 | |
B | ASN296 | |
B | LYS344 | |
C | ARG249 | |
C | ASN296 | |
C | LYS344 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9R186 |
Chain | Residue | Details |
A | ASP682 | |
B | ASP682 | |
C | ASP682 | |
D | ASP682 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine; by LYN => ECO:0000305|PubMed:12538589 |
Chain | Residue | Details |
A | TYR253 | |
B | TYR253 | |
C | TYR253 | |
D | TYR253 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:16368742 |
Chain | Residue | Details |
A | ASN651 | |
B | ASN651 | |
C | ASN651 | |
D | ASN651 |