8JIS
Cryo-EM structure of the GLP-1R/GCGR dual agonist peptide15-bound human GLP-1R-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 356 | 41401.9 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63096) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 338 | 37198.7 | 1 | UniProt (P54311) Pfam (PF25391) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 3 | C (P) | Peptide 15 | polymer | 29 | 3385.7 | 1 | synthetic construct | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 57 | 6261.2 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (cattle) | G gamma-I |
| 5 | E (N) | Nanobody 35 | polymer | 126 | 13711.3 | 1 | Escherichia coli | ||
| 6 | F (R) | Glucagon-like peptide 1 receptor | polymer | 394 | 46130.5 | 1 | UniProt (P43220) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (human) | GLP-1 receptor,GLP-1-R,GLP-1R |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 148089.2 | |
| All* | Total formula weight | 148089.2 |
