8JHR

Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sphingosine-1-phosphate transporter SPNS2	polymer	571	60621.9	1	UniProt (Q8IVW8) Pfam (PF07690)	Homo sapiens (human)	Protein spinster homolog 2
2	B (A)	3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine	non-polymer		343.5	1	Chemie (YUX)

Sequence modifications

A: 1 - 549 (UniProt: Q8IVW8)

PDB	External Database	Details
Met -21	-	initiating methionine
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Asp -8	-	expression tag
Glu -7	-	expression tag
Val -6	-	expression tag
Asp -5	-	expression tag
Ala -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	60621.9
Non-Polymers*	Number of molecules	1
	Total formula weight	343.5
All*	Total formula weight	60965.4

*Water molecules are not included.