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8JHR

Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d

Functional Information from GO Data
ChainGOidnamespacecontents
A0001782biological_processB cell homeostasis
A0002260biological_processlymphocyte homeostasis
A0002920biological_processregulation of humoral immune response
A0003376biological_processsphingosine-1-phosphate receptor signaling pathway
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0006665biological_processsphingolipid metabolic process
A0006869biological_processlipid transport
A0007605biological_processsensory perception of sound
A0010008cellular_componentendosome membrane
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0030148biological_processsphingolipid biosynthetic process
A0043029biological_processT cell homeostasis
A0046624molecular_functionsphingolipid transporter activity
A0048073biological_processregulation of eye pigmentation
A0048535biological_processlymph node development
A0055085biological_processtransmembrane transport
A0060348biological_processbone development
A0072676biological_processlymphocyte migration
A2000404biological_processregulation of T cell migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues220
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AGLY141-LEU161
ATHR466-ILE486
ALEU507-VAL527
AVAL169-PRO189
ALEU202-PHE222
ALEU229-GLY249
ATRP261-VAL281
ALEU320-LEU340
ALEU364-ALA384
ALEU398-ALA418
AILE422-ILE442

236620

PDB entries from 2025-05-28

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