8JHQ

Cryo-EM structure of human S1P transporter SPNS2 bound with S1P

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sphingosine-1-phosphate transporter SPNS2,GlgA glycogen synthase	polymer	764	82089.9	1	UniProt (Q8IVW8) UniProt (Q9V2J8) Pfam (PF07690)	Homo sapiens (human)	Protein spinster homolog 2,Glycogen synthase
2	B (A)	(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate	non-polymer		379.5	1	Chemie (S1P)

Sequence modifications

A: 1 - 222 (UniProt: Q8IVW8)

PDB	External Database	Details
Met -18	-	initiating methionine
Asp -17	-	expression tag
Tyr -16	-	expression tag
Lys -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Asp -11	-	expression tag
Lys -10	-	expression tag
Leu -9	-	expression tag
Glu -8	-	expression tag
Val -7	-	expression tag
Leu -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

A: null - null (UniProt: Q9V2J8)
A: null - 745 (UniProt: Q8IVW8)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	82089.9
Non-Polymers*	Number of molecules	1
	Total formula weight	379.5
All*	Total formula weight	82469.4

*Water molecules are not included.