8JD3
Cryo-EM structure of Gi1-bound mGlu2-mGlu3 heterodimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | Metabotropic glutamate receptor 2 | polymer | 870 | 95684.3 | 1 | UniProt (Q14416) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (human) | mGluR2 |
| 2 | B (3) | Metabotropic glutamate receptor 3 | polymer | 894 | 100810.3 | 1 | UniProt (Q14832) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (human) | mGluR3 |
| 3 | C (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 4 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | |
| 5 | E (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 6 | F (2) | 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one | non-polymer | 344.9 | 1 | Chemie (HZR) PubChem (25195461) | |||
| 7 | G, I (2, 3) | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032) | |||
| 8 | H, J, K (2, 3) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) PubChem (304) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (638019) PubChem (1549081) PubChem (1553803) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (6419195) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (16219173) PubChem (16758052) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (176980071) PubChem (45044259) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (49853509) PubChem (44654663) PubChem (46937002) PubChem (59274407) PubChem (50990013) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (1551269) PubChem (90070115) PubChem (52934537) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (56621683) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (57915018) PubChem (57939063) PubChem (138967089) PubChem (58428240) PubChem (58445498) PubChem (139566851) PubChem (58663286) PubChem (15939944) PubChem (59450329) PubChem (59628412) PubChem (171828367) PubChem (173516975) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (101624109) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 9 | L (3) | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE | non-polymer | 692.0 | 1 | Chemie (PEF) PubChem (445468) PubChem (65109) PubChem (15859389) |
Sequence modifications
2: 19 - 872 (UniProt: Q14416)
3: 23 - 879 (UniProt: Q14832)
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Asp 9 | - | expression tag |
| Tyr 10 | - | expression tag |
| Lys 11 | - | expression tag |
| Asp 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Asp 14 | - | expression tag |
| Asp 15 | - | expression tag |
| Gly 16 | - | expression tag |
| Ala 17 | - | expression tag |
| Pro 18 | - | expression tag |
| Leu 873 | - | expression tag |
| Glu 874 | - | expression tag |
| Val 875 | - | expression tag |
| Leu 876 | - | expression tag |
| Phe 877 | - | expression tag |
| Gln 878 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 1 | - | expression tag |
| Pro 2 | - | expression tag |
| Trp 3 | - | expression tag |
| Ser 4 | - | expression tag |
| His 5 | - | expression tag |
| Pro 6 | - | expression tag |
| Gln 7 | - | expression tag |
| Phe 8 | - | expression tag |
| Glu 9 | - | expression tag |
| Lys 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ser 12 | - | expression tag |
| Gly 13 | - | expression tag |
| Ser 14 | - | expression tag |
| Trp 15 | - | expression tag |
| Ser 16 | - | expression tag |
| His 17 | - | expression tag |
| Pro 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Phe 20 | - | expression tag |
| Glu 21 | - | expression tag |
| Lys 22 | - | expression tag |
| Leu 880 | - | expression tag |
| Glu 881 | - | expression tag |
| Val 882 | - | expression tag |
| Leu 883 | - | expression tag |
| Phe 884 | - | expression tag |
| Gln 885 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ala 245 | Glu 245 | conflict |
| Ser 326 | Ala 326 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | initiating methionine |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 283514.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2491.1 | |
| All* | Total formula weight | 286005.2 |
