8JBF
Senktide bound to active human neurokinin 3 receptor in complex with Gq
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Neuromedin-K receptor | polymer | 394 | 44317.0 | 1 | UniProt (P29371) Pfam (PF00001) | Homo sapiens (human) | NKR,NK-3 receptor,NK-3R,Neurokinin B receptor,Tachykinin receptor 3 |
| 2 | B (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 377 | 41042.8 | 1 | UniProt (P54311) Pfam (PF00400) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 3 | C (E) | ScFv16 nanobody | polymer | 304 | 32708.5 | 1 | Mus musculoides | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (cattle) | G gamma-I |
| 5 | E (A) | Senktide | polymer | 8 | 915.0 | 1 | Homo sapiens | ||
| 6 | F (C) | Guanine nucleotide-binding protein Gq subunit alpha | polymer | 361 | 41694.3 | 1 | Homo sapiens |
Sequence modifications
D: 2 - 340 (UniProt: P54311)
| PDB | External Database | Details |
|---|---|---|
| His -10 | - | expression tag |
| Met -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Asp 130 | Glu 130 | conflict |
| Asp 132 | Asn 132 | conflict |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 168538.8 | |
| All* | Total formula weight | 168538.8 |
