8JAT

Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	3-ketodihydrosphingosine reductase TSC10	polymer	275	29768.9	1	UniProt (P0CR36) Pfam (PF00106) In PDB	Cryptococcus neoformans var. neoformans JEC21	3-dehydrosphinganine reductase,KDS reductase
2	A	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	1	Chemie (NDP)
3		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A: 29 - 293 (UniProt: P0CR36)

PDB	External Database	Details
Met 28	-	initiating methionine
Phe 190	Tyr 190	engineered mutation
Ser 294	-	expression tag
Gly 295	-	expression tag
Ser 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag
His 299	-	expression tag
His 300	-	expression tag
His 301	-	expression tag
His 302	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29768.9
Non-Polymers*	Number of molecules	1
	Total formula weight	745.4
All*	Total formula weight	30514.3

*Water molecules are not included.