8JAT

Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006666	biological_process	3-keto-sphinganine metabolic process
A	0030148	biological_process	sphingolipid biosynthetic process
A	0047560	molecular_function	3-dehydrosphinganine reductase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Motif: {"description":"GXSXG","evidences":[{"source":"UniProtKB","id":"P40471","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"O93868","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Lowers pKa of active site Tyr","evidences":[{"source":"UniProtKB","id":"O93868","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PDB","id":"8JAT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O93868","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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