8JAT

Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006666	biological_process	3-keto-sphinganine metabolic process
A	0030148	biological_process	sphingolipid biosynthetic process
A	0047560	molecular_function	3-dehydrosphinganine reductase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:O93868

Chain	Residue	Details
A	PHE190

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Lowers pKa of active site Tyr => ECO:0000250|UniProtKB:O93868

Chain	Residue	Details
A	LYS194

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: BINDING => ECO:0007744|PDB:8JAT

Chain	Residue	Details
A	GLY42
A	SER44
A	SER45
A	GLY46
A	ARG67
A	ASP68
A	LYS71
A	ASP95
A	LEU96

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O93868

Chain	Residue	Details
A	PHE190
A	LYS194

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:L0E2Z4

Chain	Residue	Details
A	ILE223

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