8JAS
Structure of CRL2APPBP2 bound with RxxGPAA degron (tetramer)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, L, M (A, B, J, K) | Amyloid protein-binding protein 2 | polymer | 585 | 66945.3 | 4 | UniProt (Q92624) Pfam (PF13424) Pfam (PF13374) | Homo sapiens (human) | Amyloid beta precursor protein-binding protein 2,APP-BP2,Protein interacting with APP tail 1 |
| 2 | B, J, N, T (E, I, L, U) | Cullin-2 | polymer | 745 | 87068.8 | 4 | UniProt (Q13617) Pfam (PF00888) Pfam (PF10557) | Homo sapiens (human) | CUL-2 |
| 3 | C, H, O, Q (C, G, M, Q) | Elongin-B | polymer | 118 | 13147.8 | 4 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 4 | D, I, P, R (D, H, N, T) | Elongin-C | polymer | 96 | 10843.4 | 4 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 5 | E, G, U (S, F, O) | SUMO-XP_211896+AA C-degron | polymer | 18 | 1913.2 | 3 | Homo sapiens (human) | ||
| 6 | K, S (R, V) | E3 ubiquitin-protein ligase RBX1, N-terminally processed | polymer | 108 | 12290.0 | 2 | UniProt (P62877) Pfam (PF12678) | Homo sapiens (human) | E3 ubiquitin-protein transferase RBX1,N-terminally processed |
| 7 | AA, BA, CA, V, W... (V, A, R, K) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) |
Sequence modifications
E, I, L, U: 2 - 745 (UniProt: Q13617)
| PDB | External Database | Details |
|---|---|---|
| Thr 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 742340.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 523.3 | |
| All* | Total formula weight | 742864.1 |
