8J80
Cryo-EM structure of hZnT7-Fab complex in zinc state 1, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-unbound conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, B) | Zinc transporter 7 | polymer | 390 | 43004.3 | 2 | UniProt (Q8NEW0) Pfam (PF01545) | Homo sapiens (human) | ZnT-7,Solute carrier family 30 member 7,Znt-like transporter 2 |
| 2 | B, F (C, D) | Light chain of YN7114-08 Fab | polymer | 218 | 24140.5 | 2 | Mus musculus | ||
| 3 | C, E (E, F) | Heavy chain of YN7114-08 Fab | polymer | 234 | 24974.1 | 2 | Mus musculus | ||
| 4 | G (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A, B: 1 - 376 (UniProt: Q8NEW0)
| PDB | External Database | Details |
|---|---|---|
| Met -13 | - | initiating methionine |
| Gly -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Val -10 | - | expression tag |
| Ala -9 | - | expression tag |
| Met -8 | - | expression tag |
| Pro -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ala -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Val -1 | - | expression tag |
| Val 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 184237.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 184303.3 |
