8J80

Cryo-EM structure of hZnT7-Fab complex in zinc state 1, determined in heterogeneous conformations- one subunit in an inward-facing zinc-bound and the other in an outward-facing zinc-unbound conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0005385	molecular_function	zinc ion transmembrane transporter activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005794	cellular_component	Golgi apparatus
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006829	biological_process	zinc ion transport
A	0006882	biological_process	intracellular zinc ion homeostasis
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0012506	cellular_component	vesicle membrane
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0031410	cellular_component	cytoplasmic vesicle
A	0031982	cellular_component	vesicle
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0042802	molecular_function	identical protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0055085	biological_process	transmembrane transport
A	0071577	biological_process	zinc ion transmembrane transport
A	1904257	biological_process	zinc ion import into Golgi lumen
A	1990674	cellular_component	Golgi cis cisterna membrane
B	0000139	cellular_component	Golgi membrane
B	0005385	molecular_function	zinc ion transmembrane transporter activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005794	cellular_component	Golgi apparatus
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006829	biological_process	zinc ion transport
B	0006882	biological_process	intracellular zinc ion homeostasis
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0012506	cellular_component	vesicle membrane
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0031410	cellular_component	cytoplasmic vesicle
B	0031982	cellular_component	vesicle
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0042802	molecular_function	identical protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0055085	biological_process	transmembrane transport
B	0071577	biological_process	zinc ion transmembrane transport
B	1904257	biological_process	zinc ion import into Golgi lumen
B	1990674	cellular_component	Golgi cis cisterna membrane

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
C	TYR196-HIS202

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	56
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	210
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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