8J7U

Cryo-EM structure of hZnT7-Fab complex in zinc-bound state, determined in outward-facing conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (A, B)	Zinc transporter 7	polymer	390	43004.3	2	UniProt (Q8NEW0) Pfam (PF01545)	Homo sapiens (human)	ZnT-7,Solute carrier family 30 member 7,Znt-like transporter 2
2	B, E (E, F)	Heavy chain of YN7114-08 Fab	polymer	234	24974.1	2		Mus musculus
3	C, D (C, D)	Light chain of YN7114-08 Fab	polymer	218	24140.5	2		Mus musculus
4	G, H (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A, B: 1 - 376 (UniProt: Q8NEW0)

PDB	External Database	Details
Met -13	-	initiating methionine
Gly -12	-	expression tag
Gly -11	-	expression tag
Val -10	-	expression tag
Ala -9	-	expression tag
Met -8	-	expression tag
Pro -7	-	expression tag
Gly -6	-	expression tag
Ala -5	-	expression tag
Glu -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Val -1	-	expression tag
Val 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	184237.9
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	184368.7

*Water molecules are not included.