8J3S

Complex structure of human cytomegalovirus protease and a macrocyclic peptide ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Assemblin	polymer	263	29130.7	4	UniProt (A0A0G2TMR2) Pfam (PF00716) UniProt (by SIFTS) (P16753)	Human betaherpesvirus 5	Protease
2	E, F, G (E, F, G)	PHE-ILE-THR-GLY-HIS-TYR-TRP-VAL-ARG-PHE-LEU-PRO-CYS-GLY	polymer	13	1699.0	3		synthetic construct
3	H, I, J, K (A, B, C, G)	water	water		18.0	23	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 256 (UniProt: A0A0G2TMR2)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Gln 143	Ala 143	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	121619.7
All*	Total formula weight	121619.7

*Water molecules are not included.