8J24
Cryo-EM structure of FFAR2 complex bound with acetic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 377 | 41055.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 2 | B (C) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (D) | Free fatty acid receptor 2 | polymer | 311 | 35256.6 | 1 | UniProt (O15552) Pfam (PF00001) | Homo sapiens (human) | G-protein coupled receptor 43 |
| 4 | D (F) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (G) | scGV16 | polymer | 297 | 31870.6 | 1 | Homo sapiens (human) | ||
| 6 | F (D) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) |
Sequence modifications
B: 0 - 338 (UniProt: P62873)
D: 1 - 311 (UniProt: O15552)
| PDB | External Database | Details |
|---|---|---|
| Met -12 | - | initiating methionine |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 339 | - | expression tag |
| Ser 340 | - | expression tag |
| Ser 341 | - | expression tag |
| Gly 342 | - | expression tag |
| Gly 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Ser 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Gly 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Ser 351 | - | expression tag |
| Ser 352 | - | expression tag |
| Gly 353 | - | expression tag |
| Val 354 | - | expression tag |
| Ser 355 | - | expression tag |
| Gly 356 | - | expression tag |
| Trp 357 | - | expression tag |
| Arg 358 | - | expression tag |
| Leu 359 | - | expression tag |
| Phe 360 | - | expression tag |
| Lys 361 | - | expression tag |
| Lys 362 | - | expression tag |
| Ile 363 | - | expression tag |
| Ser 364 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 2 | Leu 2 | conflict |
| Val 36 | Ile 36 | conflict |
| Ile 80 | Val 80 | variant |
| Gly 86 | Ser 86 | conflict |
| Asn 158 | Ser 158 | variant |
| Glu 171 | Asn 171 | conflict |
| Thr 208 | Ser 208 | conflict |
| His 211 | Leu 211 | variant |
| Phe 246 | Tyr 246 | variant |
| Tyr 247 | His 247 | conflict |
| Leu 290 | Val 290 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 156459.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 59.0 | |
| All* | Total formula weight | 156518.4 |
