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8J24

Cryo-EM structure of FFAR2 complex bound with acetic acid

Functional Information from GO Data
ChainGOidnamespacecontents
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0000287molecular_functionmagnesium ion binding
C0001664molecular_functionG protein-coupled receptor binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005813cellular_componentcentrosome
C0005834cellular_componentheterotrimeric G-protein complex
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0016020cellular_componentmembrane
C0019001molecular_functionguanyl nucleotide binding
C0019003molecular_functionGDP binding
C0030496cellular_componentmidbody
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
C0031749molecular_functionD2 dopamine receptor binding
C0031821molecular_functionG protein-coupled serotonin receptor binding
C0043434biological_processresponse to peptide hormone
C0043949biological_processregulation of cAMP-mediated signaling
C0046872molecular_functionmetal ion binding
C0051301biological_processcell division
C0060236biological_processregulation of mitotic spindle organization
C0070062cellular_componentextracellular exosome
C0072678biological_processT cell migration
C1904322biological_processcellular response to forskolin
C1904778biological_processpositive regulation of protein localization to cell cortex
D0002232biological_processleukocyte chemotaxis involved in inflammatory response
D0002376biological_processimmune system process
D0002385biological_processmucosal immune response
D0002673biological_processregulation of acute inflammatory response
D0002720biological_processpositive regulation of cytokine production involved in immune response
D0002752biological_processcell surface pattern recognition receptor signaling pathway
D0002879biological_processpositive regulation of acute inflammatory response to non-antigenic stimulus
D0004930molecular_functionG protein-coupled receptor activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006954biological_processinflammatory response
D0007186biological_processG protein-coupled receptor signaling pathway
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0008289molecular_functionlipid binding
D0016020cellular_componentmembrane
D0019915biological_processlipid storage
D0032024biological_processpositive regulation of insulin secretion
D0032722biological_processpositive regulation of chemokine production
D0032757biological_processpositive regulation of interleukin-8 production
D0042593biological_processglucose homeostasis
D0042995cellular_componentcell projection
D0045444biological_processfat cell differentiation
D0046676biological_processnegative regulation of insulin secretion
D0071398biological_processcellular response to fatty acid
D0090276biological_processregulation of peptide hormone secretion
D1990806biological_processligand-gated ion channel signaling pathway
F0005515molecular_functionprotein binding
F0005834cellular_componentheterotrimeric G-protein complex
F0005886cellular_componentplasma membrane
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
F0016020cellular_componentmembrane
F0031681molecular_functionG-protein beta-subunit binding
F0048144biological_processfibroblast proliferation
F0070062cellular_componentextracellular exosome
F0071380biological_processcellular response to prostaglandin E stimulus
F0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. CSTwLLAGISIERYLgV
ChainResidueDetails
DCYS95-VAL111

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU68-SER82
BILE155-ILE169
BLEU283-ALA297
BVAL325-GLY339

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
FALA-2
DPRO63-LEU84
DGLN148-LEU173
DSER241-ARG255

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
FCYS64
CTHR181

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
FCYS64

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
DALA42-LEU62

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
DTHR85-ILE105

site_idSWS_FT_FI6
Number of Residues44
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
DGLU106-GLY126
DTHR195-ARG219

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
DVAL127-VAL147

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
DASP174-VAL194

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
DALA220-VAL240

site_idSWS_FT_FI10
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
DSER256-SER276

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN151
DASN167

222926

PDB entries from 2024-07-24

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