8IJV
Cryo-EM structure of the gastric proton pump with bound DQ-02
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium/potassium-transporting ATPase subunit alpha | polymer | 1033 | 114325.5 | 1 | UniProt (F1RM59) Pfam (PF09040) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00702) Pfam (PF00689) UniProt (by SIFTS) (P19156) | Sus scrofa (pig) | |
| 2 | B (B) | Potassium-transporting ATPase subunit beta | polymer | 290 | 33113.8 | 1 | UniProt (P18434) Pfam (PF00287) | Sus scrofa (pig) | Gastric H(+)/K(+) ATPase subunit beta,Proton pump beta chain,gp60-90 |
| 3 | C, E, F, G, I (A, B) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 5 | Chemie (PCW) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | H (A) | 4-[[5-chloranyl-2-(4-chlorophenyl)phenyl]methoxy]-N-methyl-but-2-yn-1-amine | non-polymer | 334.2 | 1 | Chemie (PWI) | |||
| 6 | J, K, L (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | M, N (B) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 8 | O, P (A, B) | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence modifications
A: 1 - 1033 (UniProt: F1RM59)
| PDB | External Database | Details |
|---|---|---|
| Ser 1005 | Gly 1006 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 147439.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 5731.1 | |
| All* | Total formula weight | 153170.5 |
