8IG0
Crystal structure of menin in complex with DS-1594b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Menin | polymer | 550 | 61105.4 | 4 | UniProt (O00255) Pfam (PF05053) | Homo sapiens (human) | |
| 2 | E, H, K, N (A, B, C, D) | (1R,2S,4R)-4-[[4-(5,6-dimethoxypyridazin-3-yl)phenyl]methylamino]-2-[methyl-[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]cyclopentan-1-ol | non-polymer | 574.6 | 4 | Chemie (7IX) | |||
| 3 | F, I, L, O (A, B, C, D) | UNKNOWN ATOM OR ION | non-polymer | 4 | Chemie (UNX) | ||||
| 4 | G, J, M, P (A, B, C, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 610 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| - | Arg 460 | deletion |
| - | Glu 461 | deletion |
| - | Ala 462 | deletion |
| - | Glu 463 | deletion |
| - | Ala 464 | deletion |
| - | Ala 465 | deletion |
| - | Glu 466 | deletion |
| - | Ala 467 | deletion |
| - | Glu 468 | deletion |
| - | Glu 469 | deletion |
| - | Pro 470 | deletion |
| - | Trp 471 | deletion |
| - | Gly 472 | deletion |
| - | Glu 473 | deletion |
| - | Glu 474 | deletion |
| - | Ala 475 | deletion |
| - | Arg 476 | deletion |
| - | Glu 477 | deletion |
| - | Gly 478 | deletion |
| - | Arg 479 | deletion |
| - | Arg 480 | deletion |
| - | Arg 481 | deletion |
| - | Gly 482 | deletion |
| - | Pro 483 | deletion |
| - | Arg 484 | deletion |
| - | Arg 485 | deletion |
| - | Glu 486 | deletion |
| - | Ser 487 | deletion |
| - | Lys 488 | deletion |
| - | Pro 489 | deletion |
| - | Glu 490 | deletion |
| - | Glu 491 | deletion |
| - | Pro 492 | deletion |
| - | Pro 493 | deletion |
| - | Pro 494 | deletion |
| - | Pro 495 | deletion |
| - | Lys 496 | deletion |
| - | Lys 497 | deletion |
| - | Pro 498 | deletion |
| - | Ala 499 | deletion |
| - | Leu 500 | deletion |
| - | Asp 501 | deletion |
| - | Lys 502 | deletion |
| - | Gly 503 | deletion |
| - | Leu 504 | deletion |
| - | Gly 505 | deletion |
| - | Thr 506 | deletion |
| - | Gly 507 | deletion |
| - | Gln 508 | deletion |
| - | Gly 509 | deletion |
| - | Ala 510 | deletion |
| - | Val 511 | deletion |
| - | Ser 512 | deletion |
| - | Gly 513 | deletion |
| - | Pro 514 | deletion |
| - | Pro 515 | deletion |
| - | Arg 516 | deletion |
| - | Lys 517 | deletion |
| - | Pro 518 | deletion |
| - | Pro 519 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 244421.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2611.0 | |
| All* | Total formula weight | 247032.4 |
