8IG0

Crystal structure of menin in complex with DS-1594b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000400	molecular_function	four-way junction DNA binding
A	0000403	molecular_function	Y-form DNA binding
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0002076	biological_process	osteoblast development
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003690	molecular_function	double-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006325	biological_process	chromatin organization
A	0006351	biological_process	DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006974	biological_process	DNA damage response
A	0008285	biological_process	negative regulation of cell population proliferation
A	0009411	biological_process	response to UV
A	0010332	biological_process	response to gamma radiation
A	0016363	cellular_component	nuclear matrix
A	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0032154	cellular_component	cleavage furrow
A	0032991	cellular_component	protein-containing complex
A	0035097	cellular_component	histone methyltransferase complex
A	0045064	biological_process	T-helper 2 cell differentiation
A	0045668	biological_process	negative regulation of osteoblast differentiation
A	0045786	biological_process	negative regulation of cell cycle
A	0045815	biological_process	transcription initiation-coupled chromatin remodeling
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046329	biological_process	negative regulation of JNK cascade
A	0051219	molecular_function	phosphoprotein binding
A	0070412	molecular_function	R-SMAD binding
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000400	molecular_function	four-way junction DNA binding
B	0000403	molecular_function	Y-form DNA binding
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0002076	biological_process	osteoblast development
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003690	molecular_function	double-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006325	biological_process	chromatin organization
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006974	biological_process	DNA damage response
B	0008285	biological_process	negative regulation of cell population proliferation
B	0009411	biological_process	response to UV
B	0010332	biological_process	response to gamma radiation
B	0016363	cellular_component	nuclear matrix
B	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0032154	cellular_component	cleavage furrow
B	0032991	cellular_component	protein-containing complex
B	0035097	cellular_component	histone methyltransferase complex
B	0045064	biological_process	T-helper 2 cell differentiation
B	0045668	biological_process	negative regulation of osteoblast differentiation
B	0045786	biological_process	negative regulation of cell cycle
B	0045815	biological_process	transcription initiation-coupled chromatin remodeling
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046329	biological_process	negative regulation of JNK cascade
B	0051219	molecular_function	phosphoprotein binding
B	0070412	molecular_function	R-SMAD binding
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000400	molecular_function	four-way junction DNA binding
C	0000403	molecular_function	Y-form DNA binding
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0002076	biological_process	osteoblast development
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003690	molecular_function	double-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006325	biological_process	chromatin organization
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006974	biological_process	DNA damage response
C	0008285	biological_process	negative regulation of cell population proliferation
C	0009411	biological_process	response to UV
C	0010332	biological_process	response to gamma radiation
C	0016363	cellular_component	nuclear matrix
C	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0032154	cellular_component	cleavage furrow
C	0032991	cellular_component	protein-containing complex
C	0035097	cellular_component	histone methyltransferase complex
C	0045064	biological_process	T-helper 2 cell differentiation
C	0045668	biological_process	negative regulation of osteoblast differentiation
C	0045786	biological_process	negative regulation of cell cycle
C	0045815	biological_process	transcription initiation-coupled chromatin remodeling
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046329	biological_process	negative regulation of JNK cascade
C	0051219	molecular_function	phosphoprotein binding
C	0070412	molecular_function	R-SMAD binding
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000400	molecular_function	four-way junction DNA binding
D	0000403	molecular_function	Y-form DNA binding
D	0000781	cellular_component	chromosome, telomeric region
D	0000785	cellular_component	chromatin
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0002076	biological_process	osteoblast development
D	0003677	molecular_function	DNA binding
D	0003682	molecular_function	chromatin binding
D	0003690	molecular_function	double-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006325	biological_process	chromatin organization
D	0006351	biological_process	DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006974	biological_process	DNA damage response
D	0008285	biological_process	negative regulation of cell population proliferation
D	0009411	biological_process	response to UV
D	0010332	biological_process	response to gamma radiation
D	0016363	cellular_component	nuclear matrix
D	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0032154	cellular_component	cleavage furrow
D	0032991	cellular_component	protein-containing complex
D	0035097	cellular_component	histone methyltransferase complex
D	0045064	biological_process	T-helper 2 cell differentiation
D	0045668	biological_process	negative regulation of osteoblast differentiation
D	0045786	biological_process	negative regulation of cell cycle
D	0045815	biological_process	transcription initiation-coupled chromatin remodeling
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046329	biological_process	negative regulation of JNK cascade
D	0051219	molecular_function	phosphoprotein binding
D	0070412	molecular_function	R-SMAD binding