8IBU
Cryo-EM structure of the erythromycin-bound motilin receptor-Gq protein complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 361 | 41724.4 | 1 | Homo sapiens (human) | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40227.0 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | |
| 3 | C (E) | scFv16 | polymer | 247 | 26277.3 | 1 | Homo sapiens (human) | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (R) | Soluble cytochrome b562,Motilin receptor,Fusion tag | polymer | 741 | 81667.0 | 1 | UniProt (P0ABE7) UniProt (O43193) Pfam (PF00001) | Escherichia coli | Cytochrome b-562,G-protein coupled receptor 38 |
| 6 | F (R) | ERYTHROMYCIN A | non-polymer | 733.9 | 1 | Chemie (ERY) PubChem (16219331) PubChem (16757675) PubChem (22489166) PubChem (22836457) PubChem (22836628) PubChem (23229191) PubChem (24797108) PubChem (44451949) PubChem (45107170) PubChem (45107190) PubChem (45107269) PubChem (45107273) PubChem (49867933) PubChem (51066560) PubChem (16219337) PubChem (16401342) PubChem (16759276) PubChem (18397931) PubChem (18528813) PubChem (21550772) PubChem (22836626) PubChem (44317775) PubChem (44547821) PubChem (44563509) PubChem (45107581) PubChem (53384904) PubChem (53384913) PubChem (50987679) PubChem (53393685) PubChem (54359201) PubChem (57357418) PubChem (57893297) PubChem (58594795) PubChem (58593559) PubChem (59022390) PubChem (59062422) PubChem (59064284) PubChem (59093569) PubChem (59284311) PubChem (59511080) PubChem (59897430) PubChem (59903654) PubChem (60009793) PubChem (60024420) PubChem (66639443) PubChem (66899541) PubChem (177390461) PubChem (177679009) PubChem (3255) PubChem (8233) PubChem (9361) PubChem (57358551) PubChem (57587180) PubChem (154401) PubChem (70897564) PubChem (71306958) PubChem (73265320) PubChem (73456721) PubChem (73946784) PubChem (456593) PubChem (467795) PubChem (489009) PubChem (86820632) PubChem (90473776) PubChem (90746906) PubChem (91434318) PubChem (91558259) PubChem (97293608) PubChem (99719271) PubChem (110189186) PubChem (6540620) PubChem (6602506) PubChem (59974395) PubChem (60044171) PubChem (60086513) PubChem (66577477) PubChem (6604221) PubChem (124226124) PubChem (124518166) PubChem (124604978) PubChem (124605145) PubChem (124605175) PubChem (124723146) PubChem (124798369) PubChem (124762348) PubChem (124822557) PubChem (9833120) PubChem (10032882) PubChem (129009922) PubChem (129125718) PubChem (129445574) PubChem (129445576) PubChem (129666958) PubChem (10897911) PubChem (132274086) PubChem (133126690) PubChem (133126790) PubChem (133550114) PubChem (133688268) PubChem (134081643) PubChem (134081274) PubChem (134693955) PubChem (71024089) PubChem (11970254) PubChem (12358519) PubChem (12358515) PubChem (12358508) PubChem (137705094) PubChem (12560) PubChem (139247122) PubChem (141945645) PubChem (89970519) PubChem (90472408) PubChem (146158524) PubChem (157254288) PubChem (97293607) PubChem (99719272) PubChem (163003493) PubChem (163003495) PubChem (165844830) PubChem (118725304) PubChem (169440260) PubChem (172897573) PubChem (124226125) PubChem (124523502) PubChem (124604979) PubChem (124605144) PubChem (124605146) PubChem (124716782) PubChem (124716783) PubChem (124723147) PubChem (124762349) PubChem (124822555) PubChem (124822558) PubChem (124870987) PubChem (6364614) PubChem (126969058) PubChem (129010384) PubChem (6604684) PubChem (6713919) PubChem (129119817) PubChem (129445575) PubChem (129627840) PubChem (129628729) PubChem (131665174) PubChem (133562871) PubChem (133602826) PubChem (134081264) PubChem (134693174) PubChem (10034134) PubChem (135026875) PubChem (138113460) PubChem (138403276) PubChem (140886742) PubChem (141646830) PubChem (12358509) PubChem (12358517) PubChem (145774355) PubChem (12966969) PubChem (155899868) PubChem (155900413) PubChem (161123720) PubChem (163003494) PubChem (163003496) PubChem (15986867) PubChem (16212992) PubChem (16213052) PubChem (166604455) PubChem (166639762) PubChem (169289157) PubChem (171114703) PubChem (172897571) |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
R: -116 - -12 (UniProt: P0ABE7)
R: 1 - 412 (UniProt: O43193)
R: 413 - 585 (PDB: 8IBU)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gln 6 | - | expression tag |
| Gly 346 | - | expression tag |
| Ser 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Gly 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Gly 356 | - | expression tag |
| Gly 357 | - | expression tag |
| Ser 358 | - | expression tag |
| Ser 359 | - | expression tag |
| Gly 360 | - | expression tag |
| Val 361 | - | expression tag |
| Ser 362 | - | expression tag |
| Gly 363 | - | expression tag |
| Trp 364 | - | expression tag |
| Arg 365 | - | expression tag |
| Leu 366 | - | expression tag |
| Phe 367 | - | expression tag |
| Lys 368 | - | expression tag |
| Lys 369 | - | expression tag |
| Ile 370 | - | expression tag |
| Ser 371 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -155 | - | initiating methionine |
| Lys -154 | - | expression tag |
| Thr -153 | - | expression tag |
| Ile -152 | - | expression tag |
| Ile -151 | - | expression tag |
| Ala -150 | - | expression tag |
| Leu -149 | - | expression tag |
| Ser -148 | - | expression tag |
| Tyr -147 | - | expression tag |
| Ile -146 | - | expression tag |
| Phe -145 | - | expression tag |
| Cys -144 | - | expression tag |
| Leu -143 | - | expression tag |
| Val -142 | - | expression tag |
| Phe -141 | - | expression tag |
| Ala -140 | - | expression tag |
| Asp -139 | - | expression tag |
| Tyr -138 | - | expression tag |
| Lys -137 | - | expression tag |
| Asp -136 | - | expression tag |
| Asp -135 | - | expression tag |
| Asp -134 | - | expression tag |
| Asp -133 | - | expression tag |
| Ala -132 | - | expression tag |
| Lys -131 | - | expression tag |
| Leu -130 | - | expression tag |
| Gln -129 | - | expression tag |
| Thr -128 | - | expression tag |
| Met -127 | - | expression tag |
| His -126 | - | expression tag |
| His -125 | - | expression tag |
| His -124 | - | expression tag |
| His -123 | - | expression tag |
| His -122 | - | expression tag |
| His -121 | - | expression tag |
| His -120 | - | expression tag |
| His -119 | - | expression tag |
| His -118 | - | expression tag |
| His -117 | - | expression tag |
| Trp -110 | Met 29 | conflict |
| Ile -15 | His 124 | conflict |
| Leu -11 | - | linker |
| Ala -10 | - | linker |
| Ser -9 | - | linker |
| Glu -8 | - | linker |
| Asn -7 | - | linker |
| Leu -6 | - | linker |
| Tyr -5 | - | linker |
| Phe -4 | - | linker |
| Gln -3 | - | linker |
| Gly -2 | - | linker |
| Gly -1 | - | linker |
| Thr 0 | - | linker |
R: 413 - 585 (PDB: 8IBU)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 197625.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 733.9 | |
| All* | Total formula weight | 198359.5 |
