8I96
Cryo-EM structure of TLR7/TH-407b complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Toll-like receptor 7 | polymer | 823 | 94745.6 | 2 | UniProt (B3Y653) In PDB | Macaca mulatta (Rhesus monkey) | |
2 | B, A | (1S,3R)-5-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]carbonyladamantan-2-one | non-polymer | 434.5 | 2 | Chemie (GJX) |
Sequence modifications
B, A: 27 - 839 (UniProt: B3Y653)
PDB | External Database | Details |
---|---|---|
Arg 23 | - | expression tag |
Ser 24 | - | expression tag |
Pro 25 | - | expression tag |
Trp 26 | - | expression tag |
Gln 167 | Asn 167 | engineered mutation |
Gln 389 | Asn 389 | engineered mutation |
Leu 440 | Ser 440 | engineered mutation |
Val 441 | Glu 441 | engineered mutation |
Pro 442 | Val 442 | engineered mutation |
Arg 443 | Gly 443 | engineered mutation |
Gly 444 | Phe 444 | engineered mutation |
Ser 445 | Cys 445 | engineered mutation |
Gln 488 | Asn 488 | engineered mutation |
Gln 799 | Asn 799 | engineered mutation |
Glu 840 | - | expression tag |
Phe 841 | - | expression tag |
Leu 842 | - | expression tag |
Val 843 | - | expression tag |
Pro 844 | - | expression tag |
Arg 845 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 189491.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 869.0 | |
All* | Total formula weight | 190360.2 |